Abstract:
The aim of the study was to research the exposure effects of generic pesticides quizalophopP-ethyl, 98,2% (QpE 1), quizalophop-P-ethyl, 95%
(QpE 2) and quizalophop-P-ethyl, 95,9% (QpE 3) on
hematological parameters of males Wistar Han rats
in the sub chronic 90-days oral toxicity study (according to OECD 408 guideline in compliance with GLP).
Doses (0; 2; 10; 100 mg/kg) were defined. Blood for
hematological measurements was studied at 4, 9,
13 weeks after QpE exposure in the same groups of
animals throughout the experiment. Hematological
parameters: RBC, HGB, HCT, erythrocyte indices
(MCV, MCH, MCHC), total amount of leukocytes
(WBC) and platelets were measured. As a result: QpE
1 in 100 mg/kg dose induced significant decrease of
MCH and MCHC after 9 weeks of exposure and significant decrease of RBC and HGB concentration after
13 weeks of exposure. QpE 2 in 100 mg/kg dose after
4 weeks of exposure caused significantly increased of
total WBC value. MCHC was significantly decreased at
the highest dose of QpE 2 in all experimental periods
compared to the control group. QpE 3 in 100 mg/kg
dose demonstrated significantly increased of total
WBC value and significant decrease of MCHC after
13 weeks of exposure. The study revealed that QpE
1, QpE 2, QpE 3 promote hematological alterations
on the high dose level. In this case, the impurities of
generic pesticides QpE can demonstrate toxicological action as adverse effects on blood system.
Description:
Laboratory of Pathology, L.I. Medved’s Scientific Center
of Preventive Toxicology, Food and Chemical Safety
Ministry of Health, Ukraine, Kiev, Prima Conferință științifico-practică națională cu participare internațională ”Siguranţa chimică și toxicologia la confluenţa dintre domenii” 24-25 noiembrie 2016 Chișinău, Republica Moldova
