Hematological study of generic pesticides quizalophop-P-ethyl

Abstract

The aim of the study was to research the exposure effects of generic pesticides quizalophopP-ethyl, 98,2% (QpE 1), quizalophop-P-ethyl, 95% (QpE 2) and quizalophop-P-ethyl, 95,9% (QpE 3) on hematological parameters of males Wistar Han rats in the sub chronic 90-days oral toxicity study (according to OECD 408 guideline in compliance with GLP). Doses (0; 2; 10; 100 mg/kg) were defined. Blood for hematological measurements was studied at 4, 9, 13 weeks after QpE exposure in the same groups of animals throughout the experiment. Hematological parameters: RBC, HGB, HCT, erythrocyte indices (MCV, MCH, MCHC), total amount of leukocytes (WBC) and platelets were measured. As a result: QpE 1 in 100 mg/kg dose induced significant decrease of MCH and MCHC after 9 weeks of exposure and significant decrease of RBC and HGB concentration after 13 weeks of exposure. QpE 2 in 100 mg/kg dose after 4 weeks of exposure caused significantly increased of total WBC value. MCHC was significantly decreased at the highest dose of QpE 2 in all experimental periods compared to the control group. QpE 3 in 100 mg/kg dose demonstrated significantly increased of total WBC value and significant decrease of MCHC after 13 weeks of exposure. The study revealed that QpE 1, QpE 2, QpE 3 promote hematological alterations on the high dose level. In this case, the impurities of generic pesticides QpE can demonstrate toxicological action as adverse effects on blood system.