Abstract:
Background: In conditions of modern denaturated environment, one of the most important tasks of medical science is to find out the possibilities
that could enlarge the adaptive-compensatory abilities of the organism. In accordance with the recent scientific data, the stability of biosystems against
the action of external factors might be enhanced 1.5-2 times, only with the help of biological methods of prophylactic. The aim was to provide a hygienic
evaluation of protective properties of Echinacea purpurea tincture in case of oral exposure of imidacloprid and sodium nitrate considering acetylation
phenotype.
Material and methods: The experiment was conducted on 36 white male rats. Intoxication was modeled by intragastric administration of imidacloprid
and sodium nitrate in the threshold doses for 28 days. Tincture of Echinacea purpurea was injected 1.5 hours before the introduction of toxins in a dose
of 0.25 ml/kg.
Results: Pretreatment with a tincture of Echinacea leads to an improvement of some indicators of health in case of combined intoxication of
imidacloprid and sodium nitrate. Changes of integral indicators (body weight, behavioral reactions) occured later, moreover, less pronounced hypoxic
syndrome, tended to normalize liver detoxication and improvement of antioxidant system were observed in the animals with the “fast” type of acetylation.
The signs of improvement in antioxidant defense were found in “slow” acetylators. At the same time, growth of total protein level of blood plasma in
“fast” and the increase in plasma cholesterol, as well as an upward trend in alanine transferase in “slow” acetylators were detected.
Conclusions: Prescription of Echinacea purpurea for the purpose of prevention of harmful effects of imidacloprid and sodium nitrate should be
performed selectively according to the type of acetylation and functional state of the liver.
Description:
Department of Hygiene and Ecology, Bukovinian State Medical University, Chernivtsi, Ukraine
