Гигиеническая оценка эффективности использования настойки эхинацеи пурпурной при комбинированной интоксикации имидаклопридом и нитратом натрия

Abstract

Background: In conditions of modern denaturated environment, one of the most important tasks of medical science is to find out the possibilities that could enlarge the adaptive-compensatory abilities of the organism. In accordance with the recent scientific data, the stability of biosystems against the action of external factors might be enhanced 1.5-2 times, only with the help of biological methods of prophylactic. The aim was to provide a hygienic evaluation of protective properties of Echinacea purpurea tincture in case of oral exposure of imidacloprid and sodium nitrate considering acetylation phenotype. Material and methods: The experiment was conducted on 36 white male rats. Intoxication was modeled by intragastric administration of imidacloprid and sodium nitrate in the threshold doses for 28 days. Tincture of Echinacea purpurea was injected 1.5 hours before the introduction of toxins in a dose of 0.25 ml/kg. Results: Pretreatment with a tincture of Echinacea leads to an improvement of some indicators of health in case of combined intoxication of imidacloprid and sodium nitrate. Changes of integral indicators (body weight, behavioral reactions) occured later, moreover, less pronounced hypoxic syndrome, tended to normalize liver detoxication and improvement of antioxidant system were observed in the animals with the “fast” type of acetylation. The signs of improvement in antioxidant defense were found in “slow” acetylators. At the same time, growth of total protein level of blood plasma in “fast” and the increase in plasma cholesterol, as well as an upward trend in alanine transferase in “slow” acetylators were detected. Conclusions: Prescription of Echinacea purpurea for the purpose of prevention of harmful effects of imidacloprid and sodium nitrate should be performed selectively according to the type of acetylation and functional state of the liver.