Some aspects of biomedical preclinical research involving laboratory animal

Abstract

Background: Animal research has enormous utility as understanding the complex interactions of molecular mechanisms, biochemical and physiological study ultimately depends on intact organisms in vivo. The use of animals for biomedical research was the subject of much debate and continues to be today. The main question of this debate is whether or not correct, morally speaking, to conduct animal research. Scientists who use animals for these purposes mean that experiments should be done as humanely as possible. They agree that animals should not be used as long as there are testing methods producing similar results. Internationally these principles are reflected in the rules developed by the Organization for Economic Cooperation and Development for Good Laboratory Practice. However, the implementation of this legislation in our country aims at purchasing proper equipment of scientific laboratories for preclinical research, monitoring biomedical ethics and ensures quality results. The experimental ethics is a prerequisite for ensuring good scientific practice. Conclusion: The existence of a regulatory body to provide advice and evaluation of experimental design becomes mandatory enforcement of the concept of ethics in laboratory animal experiments.