IRMS - Nicolae Testemitanu SUMPh: Recent submissions

  • Combined administration of docetaxel and apigenin inhibits breast cancer cell survival and migration 
    Nizamudeen, Fathima (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Breast cancer, an urgent global health issue, necessitates innovative therapeutic approaches. This study focuses on HER2-positive breast cancer characterized by overexpression of the HER2 gene. Apigenin, a ...
  • Etiology and diagnostic particulars of benign ovarian tumors 
    Ambrosiv, Ana (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. According to the official data, the most widespread diseases of the reproductive system, at women of reproductive age, are ovarian tumors. The research results address the etiology and diagnosis of benign ...
  • Histological and immunohistochemical particularity of pectoralis gland cancer. Retrospective study in Oncology Institute from Moldova (2017-2022) 
    Ameena, Jasmin Rahman Nareekode Paramba Mujeeb Rahman (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Pectoral Gland cancer in men is rare and occurs in 0.5-1% of all breast cancers. The risk factors are various, but the most common are the genetic mutation of BRCA2, familial history, and hormone disbalance. ...
  • The role of predictive factors of hemorrhagic transformation in patients with ischemic stroke undergoing intravenous thrombolysis 
    Frimu, Anastasia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Intravenous thrombolysis (IT) is the standard intervention for patients with ischemic stroke that demonstrates a significant rate of reduction in mortality and disability. Hemorrhagic transformation (HT) after ...
  • Advancing Parkinson's disease management: novel strategies and therapeutic innovations 
    Budianu, Cătălina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Parkinson's disease is a long-term neurodegenerative condition of the central nervous system that mainly affects the control of voluntary movements due to the gradual degeneration of dopaminergic neurons ...
  • Contemporary approaches to the treatment of frontotemporal dementia 
    Iarovoi, Alexandru (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Frontotemporal dementia or FTD relates to a group of diseases that are caused by neuronal degeneration. FTD is mainly of genetic etiology, due to mutations occurring in specific genes, and may be transmitted ...
  • Mesenchymal stem cell-derived exosomes and their antineoplastic potential 
    Louka, George (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Mesenchymal stem cells (MSC) are pluripotent cell types derived from mesenchyme able to differentiate and proliferate into a variety of tissues. Exosomes derived from MSC exhibit a round morphology (40-160 ...
  • Gene therapy for adenosine deaminase severe combined immunodeficiency (ADA-SCID) 
    Bogdanov, Alan (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. About 1 in 500,000 people are born with severe combined immunodeficiency (SCID). The adenosine deaminase variant is a fatal inborn error of purine metabolism. Accumulation of adenosine and deoxyadenosine ...
  • Combination of beta-blockers with ace inhibitors in the treatment of hypertension in patients with cardiac comorbidities 
    Ticlenco, Teodorina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Approximately 1.28 billion people worldwide are estimated to have hypertension, and it can either promote or accompany other cardiac comorbidities. The combination of betablockers with angiotensin-converting ...
  • Mechanisms of drug-induced nephrotoxicity 
    Iapara, Olga (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Drug-induced nephrotoxicity or drug-induced renal disease (DRID) is a common clinical problem. It has been reported that the incidence of drug-induced renal disease in adults can range from 14-26% to 66% ...
  • Drugs of choice in hypertensive emergency associated with acute aortic dissection 
    Prijilevschi, Cristina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Acute aortic dissection is a hypertensive emergency that requires an immediate reduction of blood pressure (BP) by administering intravenous drug therapy. Diligent control of BP is the most crucial in order ...
  • Acute drug intoxication - a modern look at old problem 
    Zveaghintev, Piotr (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Acute drug intoxication is a persistent and critical problem in the modern healthcare landscape. Study of the problem in recent years has marked an increase in the incidence of acute poisoning. Given the ...
  • Dapagliflozin as an SGLT2 inhibitor and its effect on the treatment of type 2 diabetes 
    Minchevici, Delia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Sodium-glucose cotransporter 2 (SGLT2) inhibitors represent a drug class commonly used in the management of type 2 diabetes. Aim of study. Dapagliflozin demonstrated a significant decrease in the occurrence ...
  • Significance of circadian rhythm for cardiac homeostasis 
    El Alamy, Hamdy (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Circadian rhythm plays a crucial role in the homeostasis of the cardiovascular system through hormonal secretion and the regulation of the nervous system's activity. Aim of study. This research aims to ...
  • The influence of circadian rhythms in the exacerbation of bronchial asthma 
    Mardari, Cristina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Asthma is an inflammatory disease of the airways, affecting 334 million people globally, of whom 44-61% are prone to developing complications during the night. One of the most important diagnostic criteria ...
  • The importance of daylight effects on the circadian rhythm and negative consequences of evening lightening of displays 
    Lungu, Alexandrina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Light is electromagnetic radiation with wavelengths between 400 and 700 nm visible to the human eye. Over recent years, a technological revolution has occurred in which conventional lightning has been replaced ...
  • The importance of melatonin in the development of idiopathic scoliosis 
    Robu, Daniela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Adolescent idiopathic scoliosis is a common disease, with a 0.47–5.2% prevalence. The female-to-male ratio ranges from 1.5:1 to 3:1 and is increasing with age. Untreated scoliosis can cause muscle imbalances, ...
  • The role of dysfunctional breathing in the pain syndrome. respiratory biofeedback and other guided breathing techniques in pain treatment 
    Lefter, Gheorghe (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Chronic pain syndrome is a global health concern that significantly impacts patients' quality of life. It stems from various conditions, including degenerative joint diseases, neurological disorders, autoimmune ...
  • The importance of the circadian rhythm in the musculoskeletal development of children 
    Stratu, Teodora (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Bone and muscle cells have the same circadian rhythm as the rest of the body's cells, with 24-hour oscillations governed by the primary clock. This review aimed to determine if there is a correlation between ...
  • Respiratory biofeedback for anxiety reduction through visualization of the chest movements 
    Gaidarlî, Loredana (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Anxiety causes significant distress to patients and remains one of the most common complaints in primary healthcare. Family physicians often find themselves seeking the most effective treatment for patients, ...