Duchenne muscular dystrophy and limb-girdle muscular dystrophy: clinical cases

Abstract

Background : Muscular dystrophies (MD) represent a large group of genetic disorders that are manifested by progressive increase of muscle weakness. Duchenne muscular dystrophy (DMD) is an X-linked disorder and limb-girdle muscular dystrophies (LGMDs) include over thirty subtypes, that are classified in autosomal dominant (1A-1H) and recessive (2A-2W). Our aims was to highlight the clinical and genetic aspects in MD by reporting two clinical cases with the aim of improving the early diagnosis.