Abstract:
Introduction. More and more scientific evidence criticizes free radicals for the occurrence of
numerous and serious conditions such as liver cirrhosis, atherosclerosis, various types of cancers,
diabetes etc. For this reason, the role of antioxidants, in defending the body from damage caused
by different types of radicals, is crucial. Although molecular oxygen plays a particularly
important role in sustaining life on this planet through its involvement in many physiological
processes (photosynthesis, aerobic respiration), it is also toxic, especially when converted to the
superoxide (O2-), anion included into the group of reactive oxygen species. Thus, in this context,
the development of new antioxidant compounds capable of neutralizing reactive oxygen species,
is essential.
Aim of the study. The present study aims to evaluate the antioxidant action of some derivatives
obtained by esterification of aryl-propionic acids with α-tocopherol.
Materials and methods. The ester-type prodrugs of tocopherol were obtained by reacting it with
derivatives of the aryl-propionic acid class (ibuprofen and ketoprofen) in absolute ethyl alcohol
medium. The resulting compounds (TOC-IBF and TOC-KTF) were physically and chemically
characterized and their structure was confirmed by IR spectroscopy. Antioxidant potential was
assessed by two spectrophotometric methods: total antioxidant capacity and reducing power.
Results. Following optimization of the synthesis method, the compounds were obtained in good
yields. IR spectra, recorded in the range of 500-4000 cm-1, revealed the group vibrations
characteristic of the structural elements specific to each compound: the ester group, the aromatic
ring and the basic structure of the tocopherol. The structural modulation of the aryl-propionic
acids has positively influenced the antioxidant properties, the action of the synthesized
compounds being comparable to that of tocopherol.
Conclusions. The results obtained in this study support the antioxidant potential of synthesized
compounds and their applications in various diseases mediated by reactive oxygen species
(ROS).
