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Obtaining and biological evaluation of α - tocopherol ester type products

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dc.contributor.author Mihalcea, Valentina
dc.date.accessioned 2020-07-07T12:02:57Z
dc.date.available 2020-07-07T12:02:57Z
dc.date.issued 2018
dc.identifier.citation MIHALCEA, Valentina. Obtaining and biological evaluation of α - tocopherol ester type products. In: MedEspera: the 7th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2018, p. 179. en_US
dc.identifier.uri https://medespera.asr.md/wp-content/uploads/Abastract-Book-2018.pdf
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/11081
dc.description Dunarea de Jos University of Galati, Galati, Romania en_US
dc.description.abstract Introduction. More and more scientific evidence criticizes free radicals for the occurrence of numerous and serious conditions such as liver cirrhosis, atherosclerosis, various types of cancers, diabetes etc. For this reason, the role of antioxidants, in defending the body from damage caused by different types of radicals, is crucial. Although molecular oxygen plays a particularly important role in sustaining life on this planet through its involvement in many physiological processes (photosynthesis, aerobic respiration), it is also toxic, especially when converted to the superoxide (O2-), anion included into the group of reactive oxygen species. Thus, in this context, the development of new antioxidant compounds capable of neutralizing reactive oxygen species, is essential. Aim of the study. The present study aims to evaluate the antioxidant action of some derivatives obtained by esterification of aryl-propionic acids with α-tocopherol. Materials and methods. The ester-type prodrugs of tocopherol were obtained by reacting it with derivatives of the aryl-propionic acid class (ibuprofen and ketoprofen) in absolute ethyl alcohol medium. The resulting compounds (TOC-IBF and TOC-KTF) were physically and chemically characterized and their structure was confirmed by IR spectroscopy. Antioxidant potential was assessed by two spectrophotometric methods: total antioxidant capacity and reducing power. Results. Following optimization of the synthesis method, the compounds were obtained in good yields. IR spectra, recorded in the range of 500-4000 cm-1, revealed the group vibrations characteristic of the structural elements specific to each compound: the ester group, the aromatic ring and the basic structure of the tocopherol. The structural modulation of the aryl-propionic acids has positively influenced the antioxidant properties, the action of the synthesized compounds being comparable to that of tocopherol. Conclusions. The results obtained in this study support the antioxidant potential of synthesized compounds and their applications in various diseases mediated by reactive oxygen species (ROS). en_US
dc.language.iso en en_US
dc.publisher MedEspera en_US
dc.subject α -tocopherol ester en_US
dc.subject prodrugs en_US
dc.subject antioxidant action en_US
dc.title Obtaining and biological evaluation of α - tocopherol ester type products en_US
dc.type Article en_US


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  • MedEspera 2018
    The 7th International Medical Congress for Students and Young Doctors, May 3-5, 2018

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