Prospects of cell therapy in the treatment of recurrent and chronic rhinosinusitis in children

Abstract

Introduction. Chronic rhinosinusitis is an important public health issue, the incidence and prevalence of which has been constantly growing in both the developing and the developed countries, having a negative impact on the quality of life and bringing about significant costs for the diagnosis and treatment. The management of recurrent ting and chronic rhinosinusitis represents a major concern for the otorhinolaryngology service. Traditionally, the treatment of recurrent and chronic rhinosinusitis has been performed by administering antibiotics, nasal irrigation with saline solution, decongestant nasal sprays, topical and systemic corticosteroids, antihistamines, antileukotrienes, and surgery as needed. Unfortunately, these methods are not free of risks and adverse effects. At the same time, the efficiency of standard treatment is lower than expected.