Abstract:
Introduction. Chronic rhinosinusitis is an important public health issue, the incidence and
prevalence of which has been constantly growing in both the developing and the developed
countries, having a negative impact on the quality of life and bringing about significant costs for
the diagnosis and treatment. The management of recurrent ting and chronic rhinosinusitis
represents a major concern for the otorhinolaryngology service. Traditionally, the treatment of
recurrent and chronic rhinosinusitis has been performed by administering antibiotics, nasal
irrigation with saline solution, decongestant nasal sprays, topical and systemic corticosteroids,
antihistamines, antileukotrienes, and surgery as needed. Unfortunately, these methods are not
free of risks and adverse effects. At the same time, the efficiency of standard treatment is lower
than expected.
