The Moldovan Medical Journal 2020: Recent submissions

  • Uterine arteriovenous malformation 
    Toncoglaz, Constantin (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: Uterine arteriovenous malformations (AVM) are extremely rare entities, with less than 100 cases reported in the literature. Synonyms for AVM are arteriovenous fistula, branched aneurysm, hemangioma, pulsating ...
  • S100 protein in molecular subtypes of breast cancer 
    Carpenco, Ecaterina (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: Cancer research is mainly focused on the tumor cells themselves, the tumor microenvironment being largely neglected. Antigen presenting cells are a heterogeneous population that infiltrates the tumor and can ...
  • Updates on classification and management of status epilepticus 
    Munteanu, Cristina; Chiosa, Vitalie; Groppa, Stanislav (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: Status epilepticus (SE) is a major medical emergency and requires not only an emergency symptomatic treatment with antiepileptic drugs (AED) but also a rapid identification and treatment of the underlying ...
  • Functional features in interstitial lung diseases 
    Calaras, Diana; Rusu, Doina; David, Aliona; Botnaru, Victor (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: Interstitial lung diseases (ILD) are a group of disorders that are generally thought to commonly share a restrictive ventilatory defect and reduced diffusing capacity for carbon monoxide (DLCO). The aim was to ...
  • Prevalence of 35delG mutation in GJB2 gene in the Moldovan population 
    Buza, Anastasia; Parii, Sergiu; Butovscaia, Cristina; Galea-Abdusa, Daniela; Radulescu, Luminita; Curocichin, Ghenadie (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: Guanine deletion 35delG in GJB2 exon 2 is the pathogenic mutation responsible for up to 70% of cases of congenital non-syndromic sensorineural hearing loss (NSHL) among Europeans. The early molecular diagnostic ...
  • Diagnosis and modern medical-surgical tactics in treatment of biliary atresia in children 
    Gîncu, Gheorghe; Gudumac, Eva; Branişte, Nina; Revenco, Ina; Haidarli, Doina; Samciuc, Oleg (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: Biliary atresia (BA) is a serious pediatric condition that tends to progress to cirrhosis, liver failure, and death within a short time. It is the result of a continuous inflammatory, sclerosing, destructive ...
  • Evolutionary particulars of COVID-19 in elderly patients 
    Popa, Ana; Negara, Anatolie; Soric, Gabriela; Popescu, Ana (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: The new SARS-CoV-2 coronavirus affects a large number of people worldwide, and the elderly are particularly affected because of their vulnerability. Thus, the elderly patients and those with comorbidities have ...
  • Modern industrial pharmaceutical forms used in dermatological practice in the Republic of Moldova 
    Znagovan, Alexandru; Gogu, Vladislav; Fetman, Margarita; Caisim, Tatiana (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: Fighting skin diseases is a strict medical, as well as socio-economic issue for the Republic of Moldova, since they may have an aesthetic and psychological impact. The author of this scientific article presented ...
  • Management of elderly patients with chronic myeloproliferative hemopathies 
    Musteata, Vasile; Stratan, Valentina; Catrinici, Larisa; Musteata, Larisa; Dudnic, Cristina (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: Chronic myeloproliferative hemopathies (CMPH) as a whole are the most common chronic leukemias in the elderly in the structure of morbidity by hematological malignancies with primary bone marrow involvement, ...
  • Clinical and serological characteristics of early systemic lupus erythematosus 
    Garabajiu, Maria; Mazur-Nicorici, Lucia; Salaru, Virginia; Curocichin, Ghenadie; Sadovici-Bobeica, Victoria; Mazur, Minodora (The Scientific Medical Association of the Republic of Moldova, 2020)
    Abstract Background: Early diagnosis in patients with systemic lupus erythematosus (SLE), which is based on the knowledge of the variability of the initial disease manifestation, followed by prompt initiation of basic ...
  • Reorganization and resilience of brain networks in focal epilepsy 
    Ciolac, Dumitru (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: Epilepsy has been considered as a brain network disorder. Advanced computational tools have granted a non-invasive window to explore the brain networks in epilepsy. Studying the reorganization of brain networks ...
  • Inflammatory glaucoma. Elements of etiology and pathology 
    Cusnir, Valeriu; Dumbraveanu, Lilia; Groppa, Liliana; Cușnir, Vitalie; Bobescu, Nicolae; Cusnir Jr, Valeriu (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: Inflammatory glaucoma, also known as uveitic glaucoma is a multifactorial process of inflammation that causes the rising of intraocular pressure (IOP) accompanied by morphological and physiological modifying ...
  • Diagnosis and management of ischemic stroke: time is critical 
    Groppa, Stanislav; Zota, Eremei; Bodiu, Adrian; Gasnas, Alexandru; Manole, Elena; Ciobanu, Natalia; Leahu, Pavel; Efremova, Daniela; Crivorucica, Igor; Glavan, Danu; Balanuta, Tatiana (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: It is predicted that stroke’s incidence and impact will increase considerably over time. Proper management of stroke depends on a reliable and urgent diagnosis that includes patient / relative - emergency team ...
  • Antimycotic activity of phenoxythiazolchloralum 
    Podgornii, Ana; Valica, Vladimir; Pogrebnoi, Serghei; Lupascu, Lucian; Uncu, Andrei; Macaev, Fliur (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: The therapeutic options in invasive candidiasis and aspergillosis are limited and don’t provide expected results. Introducing a new drug in the therapeutic practice can improve the quality of life of ...
  • The influence of entomological preparations on oxidative stress in subacute inflammation 
    Guțu, Ina (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: It was found out that the development of oxidative stress in the inflammatory processes is determined by the action of harmful factors, as well as by the activity of leukocytes, macrophages, monocytes with the ...
  • Particularities of ensuring with medicines the patients with rare diseases in the Republic of Moldova 
    Zgircu, Elena (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: To ensure rare disease patients with medicines is a challenge for the health system. Treatments for rare diseases are very expensive, so the main financial burden for providing patients with medicines lies ...
  • The role of endothelin-1 in the doxorubicin cardiotoxicity 
    Tacu, Lilia (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: The cardiotoxicity of doxorubicin (Dx), an antineoplastic drug, is imposed by the development of cardiomyopathy and heart failure. The expression of endothelin-1 (ET-1) in myocardium under the action of Dx, ...
  • Compatibility determination of potassium orotate with spironolactone by high-performance liquid chromatography 
    Mazur, Ecaterina; Schmid, Martin; Uncu, Livia (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: Compatibility determination between active pharmaceutical ingredients (APIs) in fixed-dose combinations is an indispensable step in the elaboration. High-performance liquid chromatography provides information ...
  • Macrophages and dendritic cells density correlates with depth of invasion in the prostate carcinoma 
    Globa, Tatiana; Globa, Lilian; David, Valeriu; Globa, Pavel; Pelin, Elina; Saptefrati, Lilian (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: Immune cells interact not only with tumor cells but also with stromal cells facilitating the progression of neoplasia. The ongoing battle between immune cells and the tumor is an important factor influencing ...
  • Determination of carotenoids in extracts from species of Tagetes and Calendula 
    Benea, Anna; Ciobanu, Cristina; Cojocaru-Toma, Maria; Ciobanu, Nicolae (The Scientific Medical Association of the Republic of Moldova, 2020)
    Background: Carotenoids have played a significant role in reducing the risk of chronic diseases. The most studied in this regard is β-carotene, present in species of Tagetes and Calendula genus. Objective of the study: ...

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