The human endometrium in primary infertility patients

Abstract

Introduction. Endometrial dysfunction represents the morpho-functional changes of the endometrium, which can be reversible or irreversible, based on disruption in molecular mechanisms that lead to infertility, embryo implantation disruption or embryo death. Aim of the study. Evaluation of clinical and morphological particularities of endometrial dysfunction in patients with primary infertility. Materials and methods. We provided a prospective study, which included 96 patients divided into 2 groups. The study group included 48 patients with primary infertility and the control group: 48 fertile patients. In both groups we performed endometrial biopsy in the proliferative phase with Pipelle endometrial suction curette. The study was approved by the Research Ethics Committee of the State University of Medicine and Pharmacy "Nicolae Testemitanu", Chisinau, Republic of Moldova (No. 79/62 of 26.04.2017). Patients have signed informed consent to participate in the research. All data management and analyses were performed using SPSS 20 and Microsoft Excel 2016. Results. The mean age in the study group was 29.0 ± 4.58 and in the control group 29.2 ± 4.29 (p = 0.801). The analysis of gynecological pathologies that had an impact on the patient included in the study showed that: the pathology of the fallopian tubes were found in L1 68.8% 0.014. Inflammatory changes in the endometrium at histological examination were in L1 79.2% (n = 38) vs L0 31.3% Conclusions. Primary infertility patients have an increased incidence of chronic salpingitis, hydrosalpinx, adhesions and endometrial dysfunction.