The contributions to the study of gout medication

Abstract

Introduction. Gout is a chronic condition caused by the disorder of uric acid metabolism, which is manifested clinically, first of all, by acute relapsing arthritis and the formation of subcutaneous gouty nodules (tofi), formed from accumulations of microcrystals of monosodium urate monohydrate. In the Republic of Moldova, gout is determined in 2.5% of the population with asymptomatic hyperuricemia, but the morbidity varies from 0.3 to 2.1%. Aim of study. The elucidation of clinical features and contemporary principles of pharmacotherapy and monitoring of gout medication. Materials and methods. We investigated 74 patients with different clinical forms of gout that were hospitalized during 2019 in the Rheumatology Unit of the Republican Clinical Hospital. Results. The prevalence by age is found in men between 51-60 years old (37.8%) and among women at 61-70 years old (4.1%). Gout is most often reported among men (93.2%), which is related to alcohol and food abuse (meat, beef, tomatoes); traumatic events, hunger and stress. According to the observation sheets, patients most frequently present a period of illness and/or worsening of the health status in the last years: 33.8% - up to 5 years and 31% - 6-10 years. There is a higher incidence of chronic tophi gout (56.8%) and idiopathic chronic gout (35.1%), which makes us conclude that patients addressed after specialized medical help in the hospital only in case of worsening health, other gout attacks. being monitored by the family doctor in ambulatory conditions. For the treatment of acute gout attacks and for their prevention more frequently is used uricodepressive treatment with: Alopurinol (95.9%), Colchicine (32.4%), Canefron (47.3%), analgesic treatment with antipyretic analgesics (39.2%), nonsteroidal antiinflammatory drugs (87.8%) and corticosteroids (16.2%). The average bed days spent by the patients in the Rheumatology Unit is 8 days. According to the observation sheets, it was established that during the winter-spring period, 58.11% of the total number of patients were undergoing treatment in hospital, which can be caused by the worsening of the disease during the cold period or by the oscillations of the temperature during spring.Conclusions. The results of study indicate a higher incidence of chronic tofacial gout (56.8%) and idiopathic chronic gout (35.1%). Patients hospitalized with chronic tofacial and idiopathic gout were predominantly on medication with uricodepressants (95.9%), antipyretic analgesics (39.2%), nonsteroidal anti-inflammatory drugs (87.8%) and steroids (16.2%) to improve their health.