The general concepts of gastro-duodenum ulcer pharmaco-and phytotherapy

Abstract

Introduction. Gastro-duodenum ulcer is a break in the inner lining of the stomach, the first part of the small intestine, or sometimes the lower esophagus. The most common symptoms of a duodenal ulcer are waking at night with upper abdominal pain (often described as a burning or dull ache), belching, vomiting, weight loss, or poor appetite. Worldwide, prevalence of the disease is estimated at 6-14% of the adult population and for Republic of Moldova is 100-120 sick persons per 10,000 population Aim of the study. Highlighting epidemiological factors, mechanism of development and treatment methods of gostro-duodenum ulcer Materials and methods. Analysis of data from the observation files of 60 patients hospitalized in Internal Diseases Department no.1 of "Clinical Hospital of the Ministry of Health", Gastrology unit, during 2019. The evaluated parameters were: gender, age, smoker or nonsmoker, place of living, basic diagnosis (type of ulcer developed), the etiology of the disease, complications, treatment, recommendations for discharge Results. The analysis of the distribution of cases of gastro-duodenum ulcer by sex showed the predominance of the male (62%) compared to the female (38%). The total number of patients diagnosed with gastric or duodenal ulcer disease rate was distributed as follows: 90% of patients developed duodenal ulcers and 10% - developed gastric ulcers. The treatment included: spasmolytics (100%), chemotherapics (80%), proton pump inhibitors and antibiotics (67%), H2 receptor antagonists (37%), antacids (22%), gastroprotectives (11%). The other medicinal remedies were indicated for symptomatic purpose: hemostatics (12%), prokinetics (5%), sedatives (58%) Conclusions. 1. Gastric and duodenal ulcer is a defect of the gastric or duodenal mucosa, which goes far beyond the muscular mucosa and is surrounded by an acute or chronic inflammatory infiltrate. 2. The most important factors that modulate the epidemiology of gastric and duodenal ulcer are genetic predisposition, Helicobacter Pylori infection (decreasing) and consumption of NSAIDs (increasing). 3. In our study, men are more often affected, because they are more frequently subjected to risk factors, such as: active and passive smoking, alcohol use, food additives and psycho-emotional pressure.