Abstract:
Introduction. Nuclear magnetic resonance (NMR) is an analysis method for studying the
magnetic properties of atomic nucleus and provides information about the number, type and spatial
position of the nucleus in the molecule. Together with infrared spectrophotometry (IR), the NMR is a
safe tool in establishing the chemical structure of unknown substances in organic synthesis, drug
designing, biochemical process description, analysis of metabolites, the chemical and pharmaceutical
analysis.
Objective of the study. To determine the chemical structure and the spatial conformation of
phenoxythiazolechloralum for designing an antimycobacterial drug.
Materials and methods. Bruker NMR spectrometer; electronic balance (Ohaus),
phenoxythiazolechloralum.
Results and discussion. In this research, the NMR spectra were obtained in relation to internal
reference standard of tetramethylsilane (TMS). The study of protonic NMR spectrum (1H1) provides
information about the chemical shifts of each type of proton and functional groups, which indicates the
presence of CH bonds in the benzene ring (2-4), the aromatic chlorine (1-6) and the alcoholic hydroxyl
group (3 -4). The NMR carbonic spectrum (13C6) demonstrates the spatial position of the functional
groups that contain carbon, namely aliphatic CH links (25-40), CH in benzene ring (125-145), C = N
(117) C = O ( 194). These results allow to present the chemical formula of phenoxythiazolechloralum.
Conclusions: According to this study was determined the chemical structure and spatial
conformation of phenoxythiazolechloralum, a drug with antimycobacterial real potential. Key words:
NMR spectroscopy, phenoxythiazolechloralum, antimycobacterial.
Description:
Chair of pharmaceutical and toxicological chemistry, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 6th International Medical Congress for Students and Young Doctors, May 12-14, 2016
