NMR analysis of phenoxythiazolechloralum

Abstract

Introduction. Nuclear magnetic resonance (NMR) is an analysis method for studying the magnetic properties of atomic nucleus and provides information about the number, type and spatial position of the nucleus in the molecule. Together with infrared spectrophotometry (IR), the NMR is a safe tool in establishing the chemical structure of unknown substances in organic synthesis, drug designing, biochemical process description, analysis of metabolites, the chemical and pharmaceutical analysis.

Objective of the study. To determine the chemical structure and the spatial conformation of phenoxythiazolechloralum for designing an antimycobacterial drug.

Materials and methods. Bruker NMR spectrometer; electronic balance (Ohaus), phenoxythiazolechloralum.

Results and discussion. In this research, the NMR spectra were obtained in relation to internal reference standard of tetramethylsilane (TMS). The study of protonic NMR spectrum (1H1) provides information about the chemical shifts of each type of proton and functional groups, which indicates the presence of CH bonds in the benzene ring (2-4), the aromatic chlorine (1-6) and the alcoholic hydroxyl group (3 -4). The NMR carbonic spectrum (13C6) demonstrates the spatial position of the functional groups that contain carbon, namely aliphatic CH links (25-40), CH in benzene ring (125-145), C = N (117) C = O ( 194). These results allow to present the chemical formula of phenoxythiazolechloralum.

Conclusions: According to this study was determined the chemical structure and spatial conformation of phenoxythiazolechloralum, a drug with antimycobacterial real potential. Key words: NMR spectroscopy, phenoxythiazolechloralum, antimycobacterial.