Efficiency of using combinational drugs in treatment of urinary lithiasis

Abstract

Introduction. Urinary lithiasis is a major global health problem with a prevalence of 2-3% of general population and a lifetime recurrence rate about of 50%. In the Republic of Moldova, 10% of the whole population suffer from this desease. The surgical treatment of urolithiasis is making conditions for improving urodinamics and reducing inflammatory process. Taking into consideration the high recurrence of urolithiasis, patients suffering from this disease need adequate and long-term treatment. Thus, safe and effective nonmedicinal prevention strategies are needed. Aim of the study. Evaluation of the efficacy of the combination drugs in treatment of urolithiasis after extracorporeal shock wave lithotripsy, ureteroscopy, percutaneous nephrolithotomy in removing of the restant fragments Materials and methods.. The research included 60 consecutive cases of the urolithiasis treated during 01 february2019-31 mai 2019. The study was effectuated in the Department of urology and surgical nephrology of the State University of Medicine and Pharmacy "Nicolae Testemitanu", within the Republican Clinical Hospital "Timofei Moşneaga". Patients were randomly divided in two groups. Group I(group of study) included 30 patients who administrated the combination drugs(citrate, magnesium, pirodoxin). Group II(control group) included 30 patients who took only general recommendations like adequate hydration, diet, limited caffeine etc. Results. The average age of the patients with urolithiasis was 47,17±14 years. In the Group I before administration of combinational drugs urine pH level was 6,2±0,8, after administration 7,1±0,3. The level of magnesium was increased: before administation 3,1±1,57 after ,9±2,2 mmol/24h. The obtained results confirm increase of daily diuresis 2275±257 ml vs 1580±321 ml; p<0,05. The presence of renal colic during the expulsion of disintegrated fragments in 1,8±0,3 cases was in the Group I and in 6,7±0,8 in the Group II. In the group of study the VAS score was 4 points, in comparison 7 points in control group.Conclusions. Administration of combinated drugs increase daily diuresis, level of megnesium and level of urine pH which is going to alkalization of urine as a result of expulsion of desintegrated fragments was increasing, as well as reduced attacks of renal colic.