Contemporary treatment of metastatic ovarian tumors

Abstract

Introduction. Metastatic ovarian cancer is a serious worldwide public health problem, with one of the highest potential for lethality among all tumors. It is an advanced malignancy, or secondary tumor, with primary other organs, most commonly the gastrointestinal tract and mammary gland, stomach, colon, appendix, uterus, lung. At present, the treatment of metastatic ovarian tumors consists of several successive stages: surgical treatment, chemotherapy and radiotherapeutic treatment. Patients with a metastatic limit only in the ovary have a favorable prognosis, or usually. Adjuvant chemotherapy after metastasis resection offers survival benefits in gastric and colorectal cancer. The ovary is a frequent site of involvement for metastases. Ovarian involvement is observed at autopsy in approximately 10% of breast cancer cases. Metastasis is bilateral around 80% of patients. About 5-30% of ovarian cancers are metastatic malignancies. Aim of the study. To study the techniques and principles of treatment for metastatic ovarian tumors Materials and methods.. Lot of patients: 53 patients with metastatic ovarians tumors were hospitalized and treated in IMSP IO from Moldova during 2012-2019 Results. Total enrolled: 53 patients, age with the highest incidence - 41-50 years - 18 patients (33.9%) Histological distribution: signet ring cell - 26 patients( 49.1%), adenocarcinoma – 24 patients ( 45.2%), clear cell carcinoma - 3 patients (5.66%). After the primary outbreak - the highest incidence for the stomach cancer - 25 patients (47.1%) and uterus cancer- 17 patients (32.07%).For the colorectal cancer the incidence is 9.43%- 5 patients, uterin cervical cancer3.77%- 2 ,mammary gland cancer-5,66%- 3 patients and for cancer without clarification-1,88 %- 1 patient. Bilaterality is prevalent in our study with 62.2% (33 persons) Of them treated surgically: 53 patients-100% ,treated only with adjuvant chemotherapy: 40 patints- 75,47 %,treated only with radiotherapy- 7 patients- 13.2 %, combined treatment- 6 patients- 11,3%. Chemotherapy treatment consists of complex treatment regimens containing at least 2 chemotherapeutic preparations. The patients has be treated with fluorouracil, doxorubicin, cisplatin, cyclophosphamide .We can mention that fluorouracil was used by 28 patients, doxorubicin-24, cisplatin -30, cyclophosphamide-14. Conclusions. Treatment for metastatic cancer aims to slow the growth or spread of the cancer. The treatment depends on the type of cancer, where it started, the size and location of the metastasis, and other factors. Even if metastatic cancer has stopped responding to treatment, many therapies may help ease side effects and improve quality of life.