Abstract:
Scope: Investigate the data and research about the contemporary aspects of the etiopathogenesis of retention and growth of urinary calculi.
Objectives: 1.To determine the uropathogenic factors involved in the formation of urinary
calculi. 2. To analyze the susceptibility of the urinary tract in developing urolithiasis. 3. To
investigate the relevant mechanism of retention and growth of urinary stones. 4. To determine the
application of the theoretical mechanism of urolithiasis in practice.
Materials and methods: Analyzing studies based on radiologic methods such as endoscopy
and computer-assisted microscopy to prove the formation of calculi on the Randall plaques and
plugs in the lumen of the collecting ducts.
Conclusions: 1. Lithogenesis represents a succession of physicochemical events which imply
the action of diverse factors in specific conditions.2. Randall plaques is the most important factor in
the pathogenesis of stone formation and their growth. 3. Plugs in the lumen of the collecting ducts
represent an important pathogenetic factor in lithogenesis, moreover this is involved in the some
forms of cortical diseases. 4. Distinguishing from the following types of stone formation and their
growth mechanisms could contribute to the understanding of calculi formation.