Modern views in the etiopathogenesis of urolithiasis

Abstract

Scope: Investigate the data and research about the contemporary aspects of the etiopathogenesis of retention and growth of urinary calculi. Objectives: 1.To determine the uropathogenic factors involved in the formation of urinary calculi. 2. To analyze the susceptibility of the urinary tract in developing urolithiasis. 3. To investigate the relevant mechanism of retention and growth of urinary stones. 4. To determine the application of the theoretical mechanism of urolithiasis in practice. Materials and methods: Analyzing studies based on radiologic methods such as endoscopy and computer-assisted microscopy to prove the formation of calculi on the Randall plaques and plugs in the lumen of the collecting ducts. Conclusions: 1. Lithogenesis represents a succession of physicochemical events which imply the action of diverse factors in specific conditions.2. Randall plaques is the most important factor in the pathogenesis of stone formation and their growth. 3. Plugs in the lumen of the collecting ducts represent an important pathogenetic factor in lithogenesis, moreover this is involved in the some forms of cortical diseases. 4. Distinguishing from the following types of stone formation and their growth mechanisms could contribute to the understanding of calculi formation.