Abstract:
Introduction: Hodgkin lymphoma is a malignant tumor of the lymphatic system. Hodgkin's
disease occurs predominantly in young adults and is one of the most curable malignancies. With
current treatment approaches, most patients achieve a lasting complete remission, but there is a high
risk of developing in these patients’ secondary malignant tumors, and the mortality is associated
with both radiotherapy and chemotherapy.
Purpose and objectives: Researching metachronous malignancies in patients with Hodgkin
lymphoma and studying the frequency of their occurrence, depending of the age, sex, clinical
stages, histological forms, the administrated treatment for Hodgkin lymphoma and also the time
period for developing secondary malignancies.
Materials and Methods: Our study is based on 53 patients diagnosed and treated for
Hodgkin Lymphoma in Oncological Institute of Republic of Moldova, all the patients where in
complete remission when they developed secondary malignancy. In our study where 22 men and 31
women, with ages between 4 and 81 years.
Results: According to our study the number of patients diagnosed with Hodgkin's was the
highest in the age o f 11-21 for women (24,5%) and 21-31 for men (24,5%). The mix cellular form
of tumors was the most frequent (43,39%). The metachronous tumors are mostly revealed in the
stage IIA (39, 62%) of the disease. Our research carried out that there is a prevalence of a combined
chemo-radiotherapy method of treatment (52.83%). The maximum risk of developing secondary
metachronous tumors occurs over 11 to 20 years (46%), and the most frequently diagnosed tumors
where lung cancer (22,64%), gastric cancer (16,98%), breast cancer( 13,20%).
Conclusions: After treatment for Hodgkin's lymphoma in patients may develop secondary
metachronous tumors that occur more frequently in women aged 21-40 years at diagnosis of Hodgkin
lymphoma. Metachronous secondary tumors are identified mainly in patients diagnosed with stage IIA
Hodgkin lymphoma, histological variant most commonly diagnosed as mixed cellularity. The method of
treatment was chosen for the majority of patient’s chemo-radiotherapeutic. Period of development of
secondary tumors is 11-20 years after treatment for Hodgkin's lymphoma. Secondary malignancies after
Hodgkin Lymphoma can have different location.
