Analiza chimico-toxicologică a alprazolamului

Abstract

There was elaborated the TLC method of alprazolam identification by using of five develop systems, spectrophotometric method of quantitative determination for apprazolam in powder and tablets of 0.001 g were elaborated, as well as HPLC method was elaborated in order to determine the purity of substance.Using the analytical methods elaborated by us over the artificial biological test there was extracted alprazolam from biological liquids (blood plasma, urine). Having considered the elaborated methods as specific and reproductive they a rerecommended for the study of alprazolam in biological liquids.

A fost elaborată metoda cromatografiei pe strat subţire de identificare a alprazolamului, utilizând 2 sisteme de solvenţi, metoda spectrofotometrică de dozare în pulbere şi comprimate 0.001 g, precum şi metoda HPLC de identificare în pulbere. Aplicând metodele analitice elaborate de noi la probele biologice „in vitro” s-a efectuat extracţia alprazolamului din lichidele biologice. Dat fiind faptul, că metodele folosite sunt specifice şi reproductive ele se recomandă pentru studierea alprazolamului în lichidle biologice.