Abstract:
Introduction: Initial studies, performed to check the interference between relapsed chronic
urticaria (RCU) and positive Helicobacter pylori (HP), showed high prevalence of Helicobacter Pylori
infection in patients with RCU and high rates of remission of urticaria after eradication therapy.
Purpose and Objectives: Evaluation of clinical and paraclinical features of relapsed chronic
urticaria associated with Helicobacter pylori infection.
Materials and Methods: The retrospective study of 60 patients with RCU hospitalized in the
Allergy Department of the Republican Clinical Hospital was performed. FEGDS with biopsy and
histological detection of HP infection was obligatory for all patients.
Results: No particularities of eruptive syndrome were found in the study group in comparison
with control group. Prevalence of dyspeptic syndrome was equally high in both groups. The
presence of the relationship between gastro-duodenal mucosa inflammation and increased titers of
anti H. pylori IgG was determined. In patients with RCU and HP infection were observed
simultaneous inflammatory gastro-duodenal pathology in 100%. The rate of erosive-ulcerous
affectations was similar in the comparison groups (13.3% and 20%).
Conclusions: The clinical manifestations are similar in patients with RCU and HP infection
and in the control group without HP. In both investigated groups the changes of gastro-duodenal
mucosa according to FEGDS data are similar: edema inflammatory injuries and hyperemia prevail
mainly on the erosive-ulcerative injuries. Anti-HP IgG in high titer correlates with edema
inflammatory injuries and hyperemia o f the gastro-duodenal mucosa, unlike erosive-ulcerative
injuries, in which the values of anti-HP IgG are not high.
