Clinical and paraclinical features of relapsed chronic urticaria associated with Helicobacter Pylori infection

Abstract

Introduction: Initial studies, performed to check the interference between relapsed chronic urticaria (RCU) and positive Helicobacter pylori (HP), showed high prevalence of Helicobacter Pylori infection in patients with RCU and high rates of remission of urticaria after eradication therapy. Purpose and Objectives: Evaluation of clinical and paraclinical features of relapsed chronic urticaria associated with Helicobacter pylori infection. Materials and Methods: The retrospective study of 60 patients with RCU hospitalized in the Allergy Department of the Republican Clinical Hospital was performed. FEGDS with biopsy and histological detection of HP infection was obligatory for all patients. Results: No particularities of eruptive syndrome were found in the study group in comparison with control group. Prevalence of dyspeptic syndrome was equally high in both groups. The presence of the relationship between gastro-duodenal mucosa inflammation and increased titers of anti H. pylori IgG was determined. In patients with RCU and HP infection were observed simultaneous inflammatory gastro-duodenal pathology in 100%. The rate of erosive-ulcerous affectations was similar in the comparison groups (13.3% and 20%). Conclusions: The clinical manifestations are similar in patients with RCU and HP infection and in the control group without HP. In both investigated groups the changes of gastro-duodenal mucosa according to FEGDS data are similar: edema inflammatory injuries and hyperemia prevail mainly on the erosive-ulcerative injuries. Anti-HP IgG in high titer correlates with edema inflammatory injuries and hyperemia o f the gastro-duodenal mucosa, unlike erosive-ulcerative injuries, in which the values of anti-HP IgG are not high.