Abstract:
Introduction: Metabolic syndrome comprises several abnormalities that occur together:
general or central adiposity, elevated blood pressure, dyslipidemia, and hyperglycemia. In addition,
several other abnormalities including those of fibrinolysis, thrombosis, inflammation, and endothelial function are strongly related to the syndrome. Elevated serum uric acid levels are commonly
seen in association with glucose intolerance, hypertension, and dyslipidemia. Accumulated
evidence have also demonstrated that serum levels of uric acid have a significant correlation with
obesity and complications of metabolic syndrome.
Materials and methods: In our study were selected about 200 patients with grade land 2
hypertension aged up to 65 years. The diagnosis of metabolic syndrome was established according
to the proposed criteria based on WHO recommendations (1998), NCEP / ATP III (2005) and IDF
(2005). We evaluated uric acid levels and hyperuricemia in patients with MS.
Results: In researched group was established a significant prevalence (57.7%) of hyperuricemia
in patients with metabolic syndrome. It was noted a proportional correlation of hyperuricemia and
insulin ressistance with increasing obesity degree. The same tendency was noted to the mean plasma
levels of uric acid in patients with metabolic syndrome. In patients with hyperuricemia average values
of the atherogenic lipid fractions (TC, TG, LDL-C) were significantly higher than in those with
normouricemia and the corresponding values of HDL-C were lower, while the TC and LDL-C levels in
patients with hyperuricemia exceeded the normative recommended by NCEP. It was also noted that in
the group of persons with hyperuricemia, hypertrigliceridemia met 2.79 times more frequently than in
individuals with normal levels of uric acid and the probability of hypertrigliceridemia in the presence of
hyperuricemia was almost 3.21 times higher.
Conclusion: Hyperuricemia, considered an index of metabolic disorders, was noted in 57.8%
of metabolic syndrome patients and significantly correlated with the values of lipid indices (TG,
LDL-cholesterol), basal glucose levels, blood pressure values and indices of obesity (body mass
index and waist circumference).
