Metabolic syndrome and hyperuricemia

Abstract

Introduction: Metabolic syndrome comprises several abnormalities that occur together: general or central adiposity, elevated blood pressure, dyslipidemia, and hyperglycemia. In addition, several other abnormalities including those of fibrinolysis, thrombosis, inflammation, and endothelial function are strongly related to the syndrome. Elevated serum uric acid levels are commonly seen in association with glucose intolerance, hypertension, and dyslipidemia. Accumulated evidence have also demonstrated that serum levels of uric acid have a significant correlation with obesity and complications of metabolic syndrome. Materials and methods: In our study were selected about 200 patients with grade land 2 hypertension aged up to 65 years. The diagnosis of metabolic syndrome was established according to the proposed criteria based on WHO recommendations (1998), NCEP / ATP III (2005) and IDF (2005). We evaluated uric acid levels and hyperuricemia in patients with MS. Results: In researched group was established a significant prevalence (57.7%) of hyperuricemia in patients with metabolic syndrome. It was noted a proportional correlation of hyperuricemia and insulin ressistance with increasing obesity degree. The same tendency was noted to the mean plasma levels of uric acid in patients with metabolic syndrome. In patients with hyperuricemia average values of the atherogenic lipid fractions (TC, TG, LDL-C) were significantly higher than in those with normouricemia and the corresponding values of HDL-C were lower, while the TC and LDL-C levels in patients with hyperuricemia exceeded the normative recommended by NCEP. It was also noted that in the group of persons with hyperuricemia, hypertrigliceridemia met 2.79 times more frequently than in individuals with normal levels of uric acid and the probability of hypertrigliceridemia in the presence of hyperuricemia was almost 3.21 times higher. Conclusion: Hyperuricemia, considered an index of metabolic disorders, was noted in 57.8% of metabolic syndrome patients and significantly correlated with the values of lipid indices (TG, LDL-cholesterol), basal glucose levels, blood pressure values and indices of obesity (body mass index and waist circumference).