Abstract:
Similar to entire organism, skin aging is the imminent intrinsic process, this being also caused by
exogen factors. Skin aging and photoaging are especially caused by the ultraviolet radiations, this being
the main reason of skin transformation in sun exposed areas.
Despite morphological and pathophysiological differences , the intrinsic and extrinsic skin aging
share several similarities on molecular level.
Primary skin aging aspects are defined by the formation of oxygen reactive species and the induction
matrix of metalloproteinases. The accumulation of fragmented collagen fibrils prevents neocollagenoses
and causes the deterioration of extracellular matrix through positive feedback methods.
The importance of the extrinsic skin aging initiated the development of several preventive therapeutic methods.
