Skin aging

Abstract

Similar to entire organism, skin aging is the imminent intrinsic process, this being also caused by exogen factors. Skin aging and photoaging are especially caused by the ultraviolet radiations, this being the main reason of skin transformation in sun exposed areas. Despite morphological and pathophysiological differences , the intrinsic and extrinsic skin aging share several similarities on molecular level. Primary skin aging aspects are defined by the formation of oxygen reactive species and the induction matrix of metalloproteinases. The accumulation of fragmented collagen fibrils prevents neocollagenoses and causes the deterioration of extracellular matrix through positive feedback methods. The importance of the extrinsic skin aging initiated the development of several preventive therapeutic methods.