Abstract:
Excessive use of antimicrobial agents led to the development of important resistance
mechanisms. The aim of the study was to observe the etiology and sensitivity of pathogen agents
isolated from patients with sepsis. We have conducted a retrospective study on 60 patients with
sepsis, hospitalized in the Infectious Diseases Clinic I from Targu Mures, over a period of 1 year
(01.03.2009 - 01.03.2010). The incidence of sepsis and septic shock, the generating infection, the
chemosensitivity of the etiological agent isolated from blood cultures, the therapy and patients
evolution, have been closely examined. An increased incidence of sepsis has been noticed at patients
aged over 50 (70%) predominantly male (66,66%). The pathogen agent has been identified at 38
patients (63,33%) as follows: gram-positive bacteria (33,33%), gram-negative bacteria (30%).
Resistance of methicillin-resistant Staphylococcus aureus (MRSA) to the known antistaphylococcal
drugs was shown, except for glycopeptides (15% of patients); resistance of pneumococci to the beta
lactam drugs (6,66% of patients), resistance of gram-negative bacteria to the aminopenicillins,
sulfonamides, aminoglycosides, third-generation cephalosporins (16,66% of patients), carbapenems
(8,33% of patients), fluoroquinolones (5% of patients). In the etiology of sepsis an increased
incidence of gram-positive bacteria has been noticed, as well as an increase in the resistance rate to
the known antimicrobial agents of methicillin-resistant Staphylococcus aureus (MRSA),
pneumococci, H influenzae, К pneumoniae, E coli, beta lactamase producing. Keywords: sepsis,
etiological agent, sensibility, antimicrobial therapy.
