Aspects of chemosensitivity of etiological agents involved in severe sistemic infections

Abstract

Excessive use of antimicrobial agents led to the development of important resistance mechanisms. The aim of the study was to observe the etiology and sensitivity of pathogen agents isolated from patients with sepsis. We have conducted a retrospective study on 60 patients with sepsis, hospitalized in the Infectious Diseases Clinic I from Targu Mures, over a period of 1 year (01.03.2009 - 01.03.2010). The incidence of sepsis and septic shock, the generating infection, the chemosensitivity of the etiological agent isolated from blood cultures, the therapy and patients evolution, have been closely examined. An increased incidence of sepsis has been noticed at patients aged over 50 (70%) predominantly male (66,66%). The pathogen agent has been identified at 38 patients (63,33%) as follows: gram-positive bacteria (33,33%), gram-negative bacteria (30%). Resistance of methicillin-resistant Staphylococcus aureus (MRSA) to the known antistaphylococcal drugs was shown, except for glycopeptides (15% of patients); resistance of pneumococci to the beta lactam drugs (6,66% of patients), resistance of gram-negative bacteria to the aminopenicillins, sulfonamides, aminoglycosides, third-generation cephalosporins (16,66% of patients), carbapenems (8,33% of patients), fluoroquinolones (5% of patients). In the etiology of sepsis an increased incidence of gram-positive bacteria has been noticed, as well as an increase in the resistance rate to the known antimicrobial agents of methicillin-resistant Staphylococcus aureus (MRSA), pneumococci, H influenzae, К pneumoniae, E coli, beta lactamase producing. Keywords: sepsis, etiological agent, sensibility, antimicrobial therapy.