Abstract:
Ovarian cancer represents a small proportion of the tumors in children and adolescents, about
3-4% of solid tumors in this age group. Little accurate information is available regarding the true
incidence of ovarian tumors in children and adolescents in Romania. The objective of this study was
to evaluate the particularities of ovarian cancer in children and adolescents, to analyze the survival
and late effects. This historical prospective study is based on the data from the medical records of 32
patients - children and adolescents - with ovarian cancer who were treated between 1990- 2008 in
Institute of Oncology Bucharest, Romania. The highest incidence was for the age group of 10-14
years (17 cases), followed by the 15-19 years old group (14 cases). The histological types were:
disgerminoma (12 cases), undifferentiated carcinoma (4 cases), differentiated carcinoma (5 cases),
endodermal sinus tumor (5 cases), mixed tumors (6 cases). Stages at the time of diagnosis were as
following: stage 1-5 cases, stage II- 10 cases, stage III- 16 cases (50% of patients) and stage IV-1
case. The primary tumor was unilateral in the majority of cases: 23 patients (72%) and bilateral for 9
patients. The treatment was multimodal. Initial management was surgical for all patients: unilateral
oophorectomy in 15 cases, bilateral oophorectomy in 8 cases and bilateral oophorectomy +
hysterectomy in 7 cases. In 1 case the purpose of the surgical intervention was citoreduction, in 3
cases- palliative surgery and in 4 cases second-look surgery (positive in 2 cases). All patients received
chemotherapy following specific protocols. Radiotherapy was used in 12 cases (pelvic and
abdominal RT in 8 cases and only pelvic RT in 4 cases) and hormonal substitution used in 3 cases.
All cases were followed-up at least 1 year after the end of the treatment. Clinical observation: In the
cured cases the procreation was conserved (2 patients with normal pregnancy, normal accouchement
and healthy child). The most frequent metastases: peritoneum, lungs, liver. Mortality: 10% (1 casestage I with incomplete treatment, 1 case stage II, 1 case stage IV). Conclusions: 1. ovarian tumors in
children and adolescents are rare, the highest incidence being at pubertal age. 2. the most frequent
histological type was germ-cell tumors. They are curable if early diagnosed. 3. Survival rate in stage
III was very good with modem multimodal treatment.
