Clinical particularities of celiac disease in children

Abstract

Introduction. Celiac disease is associated with immune-mediated enteropathy, caused by intolerance to gluten and related proteins, which occurs in people with genetic susceptibility. Aim of study. Evaluation of the particularities of clinical and paraclinical picture suggestive of diagnosis of celiac disease in children. Methods and materials. Retrospective study, 40 studies (age 6 months-18 years). Serological confirmation of celiac disease: anti-tTG IgA> 10 g / l; Anti-tTG IgG <3 g / l; Total IgA 0.3-1.2 g / l for age <12 years and 0.8-2.8 g / l for 12-15 years. Laboratory tests; FGDS with duodenal biopsy; USG abdominal organs; radiological examination of the radiocarpal joint. Descriptive statistics, Microsoft Office Excel 2010. Results. Girls / boys ratio = 1/1; the high incidence of BC 37.5% was identified in the age group 0-3 years; 60% of the lot - represents the typical form of BC; in 35% of patients - BC was confirmed both serologically and histologically. 60% of children have as a risk factor - artificial / mixed feeding plus early diversification; Children who fully comply with the agglutinative diet represent 55.5%, and do not show growth retardation. The average age of diagnosis in patients without physical retardation is 9 months. Conclusion. (1) Polymorphic clinical picture, depending on the present clinical form and age. Three predominant syndromes were identified: dyspeptic syndrome, pain, and astheno-vegetative syndrome. (2) The importance of early detection of CD has been demonstrated for the initiation of agliadinic treatment in order to prevent complications of the pathology.