Abstract:
Introduction. The detailed study of the interaction of transdermal patches with the human body is the key
moment for the development of a new therapeutic era, since the technology of preparation is the main factor
on which the efficacy of any drug depends. Due to the multiple adverse reactions to the administration of
tablets and other pharmaceutical forms, modern technologies present a new transdermal patch drug form to
the pharmaceutical.
Aim of study. To highlight the advantages and efficacy of the use of transdermal patches in relation to
other pharmaceutical forms (tablets, injectable solutions).
Methods and materials. Bibliographical sources such as NCBI, PubMed and others were analysed, as well
as research and observation methods were used, by means of a questionnaire in which more than 100 people
responded, including patients, teachers, students and pharmacists.
Results. Transdermal patch is an adhesive, transdermal pharmaceutical form in which the active substance
penetrates the skin and reaches the bloodstream. They do not have a high popularity among patients,
compared to tablets. Advantages include non-invasive, painless administration, reduced frequency of
adverse reactions and avoidance of the first hepatic passage.Of those surveyed, the majority had used for
the first time transdermal patches from the analgesic class containing active ingredients extracted from
medicinal plants: capsaicin, L-menthol, eucalyptus oil, camphor and others. Of the synthetic substances
diclofenac sodium is used, while no respondent used opioid analgesic. The majority of patients confirmed
that the transdermal patches that they had used were been bought abroad,because according to the State
Nomenclature of Medicines of the Republic of Moldova it contains a small assortment, the most common
being contraceptives with levonorgestrel and preparations with opioid analgesic-fentanyl. Compared to the
transdermal patch, tablets have several disadvantages, among which the mucosal irritation and/or increased
acidity, furthermore unstable concentration of the drug leads to increased frequency of its administration
and to the occurrence of adverse reactions, low bioavailability compared to the transdermal patch. In turn,
injectable solutions present an invasive, painful pharmaceutical form that requires qualified medical
personnel.
Conclusion. The transdermal patch is one of the most convenient pharmaceutical forms used by the patient.
Rapid therapeutic effects and no side effects in therapeutic doses. The use of transdermal patches is possible
in unconscious patients or patients who have contraindication to per os administration.
