Abstract:
Introduction. Most soft gelatin capsules are made of gelatin, which due to its physical properties makes it
an ideal excipient for processing in the machine with rotating molds. There are a large number of factors
that determine the selection of soft capsules as a drug release system. But the main reason why soft capsules
are selected as the most appropriate dosage form is to increase the absorption of the drug compared to other
pharmaceutical forms.
Aim of study. Highlighting modern technologies in the manufacture of soft capsules and assortment of
medicinal substances encapsulated in flexible capsules.
Methods and materials. The bibliographic sources were analysed: NCBI platform, PubMed, DrugBunk,
Pharmatech, Pharmaceutical-technology and others
Results. The hermetically sealed soft gelatin capsules are made in one piece and can be filled with liquids,
semi-solids and even solids. Newly discovered molecules of active substances have a generally
hydrophobic tendency and are therefore poorly soluble in aqueous systems. In this case, for oral
administration, it is more difficult to formulate a water-soluble active substance in the form of a product
from which it is completely released and well absorbed into the body. a liquid preparation that contains the
active substance in liquid form and can be encapsulated. However, due to economic, technological or
patient-dependent difficulties, soft capsules are manufactured in relatively small quantities worldwide. We
differentiate several processes for the manufacture of soft gelatin capsules: by immersion (immersion), by
pressing (stamping); and by dripping. One of the most widely used methods today is the method of pressing,
which involves pressing or compressing a certain amount of wrapping product between two sheets of
gelatin in a machine that welds the capsules to the edges and at the same time cuts them (device called
capsule). The most commonly used encapsulation products are: volatile oils, esters, alcohols and organic
acids, vitamin D and analogues, estradiol and other hormones, carbicol, water-soluble vitamins associated
with fat-soluble ones, moisture-sensitive substances such as enzymes, antibiotics, fish, gaiacol and others.
For example, in the State Nomenclature of Medicines of the Republic of Moldova we find the following
soft gelatin capsules Hidroferol 0,266mg, Gofen 400, Vitamin E, Vamelan, Avodart® and others.
Conclusion. The absorption of the drug substance from the soft capsules increases, compared to its release
from a solid form (powders or tablets), which is very important from a therapeutic point of view. Patients
prefer soft capsules because they are easy to swallow, do not taste unpleasant and have pharmaceutical
elegance: modern, new, attractive appearance. Manufacturing methods in industry are automated and in
continuous flow, with high efficiency. The assortment of medicinal substances encapsulated in flexible
capsules is large and with a wide spectrum of action in the treatment of various diseases.
