Abstract:
Introduction. Headache is one of the most common neurological symptoms seen in patients with COVID19, which drastically decreases the quality of life. It can be installed de novo, with a worsening of the preexisting primary or secondary headache.
Aim of study. Description of clinical features of headache in patients with COVID-19, reveal of the typical
clinical pattern.
Methods and materials. For this review, various sources (5 cross-sectional, 1 retrospective, 1 case-control,
1 descriptive survey study, and 2 meta-analysis), published in the last two years, were selected from
PubMed, Google Scholar, Elsevier scientific databases. Data were analysed according to the following
criteria: gender; pain location, character, severity, progression; associated symptoms and history of preexisting headache.
Results. A review of several studies found that women are more likely to develop COVID-19 headaches,
although men are more likely to be infected. The most typical headache location has been shown to be
holocranial or bilateral frontal. The main character of the headaches was the oppressive one. Most of the
patients had mild to moderate pain severity, with VAS data ranging from 6 to 7.5 points. It is noteworthy
that men present more severe pain attacks than women. This may be due to the higher number of
comorbidities among male patients. According to the studies, headache mainly resolved in the first month
after COVID-19, and in 8-15% - in the first 6 months after infection, indicating a tendency towards
chronicity. Typical associated symptoms accompanying headache in COVID-19 are nausea, vomiting,
photo- and phonophobia, the most common being nausea and photophobia. Patients with a history of
tension-type headache or migraine showed a greater tendency to develop headache in COVID-19. These
patients also often experience a change in the clinical pattern of headache, with headache becoming more
severe, with longer, more frequent attacks and a tendency towards chronicity. However, the absence of
headache in the history does not exclude the possibility of developing chronic headache post-COVID-19.
Conclusion. 1. Headache intensity in most of the described cases ranged from mild to moderate, frontal or
holocranial with pressure sensation, without nausea, vomiting, phono- or photophobia. These features
might suggest a phenotypic classification of tension-type headache according to ICHD-3. 2. Two studies
with mostly female participants showed that the typical clinical headache pattern following COVID-19 was
the migraine with pulsatile pain character and association of photo- and phonophobia. These data can be
explained by the fact that migraine is a predominant type of primary headache among female patients.
Further investigation of the gender-dependent influence of COVID-19 is needed for clarification.
