Abstract:
Introduction.
COVID-19 pandemic has an impact on HF management,
possibly leading to an increase in HF mortality, while
history of HF is a risk factor for a more severe clinical
course of COVID-19.
Purpose.
The aim of our study is to analyze the complex
interconnection between the COVID-19 and heart
failure events.
Material and methods.
The research included 89 COVID-19 patients, admitted to
the cardiology department 18-91 years, the mean age
being of 67,23 ± 13,20 years, whereas 47% (42 pts) were
men and 53% (47 pts) were women. Physical
examination, ecg and echocardiography, laboratory
parameters were collected: general blood count,
natriuretic peptides, aspartate aminotransferase (AST),
alanineaminotransferase (ALT), albumin, creatinine,
serum sodium and potassium, D-dimers, and INR.
Results.
Of all patients in the CVDRF (cardiovascular disease risk
factors) cohort, 13 (15%) patients experienced, HF
events at admission or during hospitalization, of which
40 (46%) patients in the HF subgroup and 7 (8%) in the
non-HF subgroup, the latter accounting for 40% of all
observed HF events. In the CVDRF cohort, patients with
an HF event were at a two-fold increased risk for inhospital mortality compared with those without HF
events, P < 0.001, OR 3.10 [2.244.29]), even after
adjustment for age, sex, risk factors, and co-morbidities.
Interaction for HF events and age was significant (P =
0.023). Age, CV diseases, CV risk factors, history of HF,
atrial fibrillation, and CKD were significantly associated
with HF events.
Conclusions.
This study demonstrates a higher mortality for
hospitalized COVID-19 patients with HF compared with
patients without HF, even after adjustment for other
conditions and co-morbidities.
