Abstract:
Introduction. Ocular involvement in seronegative spondyloarthritis
(SASN) is a current problem with the frequency and
severity of ocular manifestations leading to decreased visual
acuity to blindness in 2.8-10% of cases. Uveitis is the most
commonly recorded manifestation among the extra-articular
symptoms of SASN.
Purpose. Highlighting the peculiarities, pathogenetic mechanisms of
ocular involvement in SASN and clinical polymorphism
based on literature data.
Material and methods. Several articles in english from 2015-2022, mostly in
PubMed, UpToDate ,NCBI databases using as keywords:
ocular involvement in SASN, PsA,ReA, SA were studied. Articles were based on prospective and retrospective studies,
including patients with ocular pathology and confirmed
SASN diagnosis.
Results. A total number of 207 SASN patients were evaluated for
ocular manifestations. In ankylosing spondylosis (AS)
53.70% had UAA(acute anterior uveitis), 28.70% had
UCA(chronic anterior uveitis), and 12.03% had dry eye
features. In psoriatic arthropathy (PsA) 14.70% had UAA,
5.88% had UCA, and 8.82% had dry eye features and 17.64%
had mild conjunctival congestion. In reactive arthritis(ReA)
37.50% had UAA, 16.66% had UCA, and 12.50% had dry
eye features and 8.33% had episcleritis.
Conclusions. In the prospective study of ocular manifestation affecting the
vast majority of patients with SASN, some or other forms of
ocular manifestation were found. Approximately 37.78% with
anterior acute uveitis , also being the most common form of
ocular involvement.
