Sindroame de afectare respiratorie la copilul cu imunodeficiențe primare

Abstract

Summary. Aim: evaluation of respiratory syndromes found in children with primary immunodeficiencies. Methods: in the study, were evaluated 14 children with primary immunodeficiencies, diagnosed in the Pneumology Clinic of IMSP Mother and Child Institute. The patients in the study were divided according to the type of PID. The patients were evaluated by methods: determination of serum Ig, determination of cellular immunity, imaging examination of the chest by Rx or CT. Results. Of 14 patients evaluated in study, 46.8% were diagnosed with primary immunodeficiencies due to antibody deficiency, and 53.2% presented with combined primary immunodeficiencies (PID). Pulmonary infections, especially pneumonia, were the most common clinical manifestations in all patients with PID. Until the establishment of the diagnosis all patients (100%) present at least one episode of pneumonia, the number of episodes being directly proportional to the age of the diagnosed. Conclusion: Complications of respiratory system diseases are frequent in primary immunodeficiencies in children, PID due to antibody deficiency being mainly associated with irreversible bronchopulmonary processes, with severe evolution.