Abstract:
Introduction: During th eyears 2006-2024, a lot of 190 patients were studied, all of which underwent
treatment in the department of oral and maxillofacial surgery, for jaw bone necrosis, caused by drug
use, bisphosphonates or radiotherapy. The patients were observed for a period of 5-15 years, some of
which needed reconstructive surgeries. For a faster formation of bone tissue were used cell transplants
and acrylic removable dentures.
Materials and Methods: The study was performed on 10 patients, who had multiple treatments in the
department of oral and maxillofacial surgery. The research contained data from the anamnesis, history
of the disease, clinical examination, and paraclinical examination. Cell transplantation was used,
collected from the ileum bone grafting and produced at The Laboratory of Tissue Engineering and
Cell Cultures of the Nicolae Testemitanu State University of Medicine and Pharmacy, in cooperation
with the Human Tissue Bank from Orthopedic and Traumatology Hospital from the Republic of
Moldova.
Results: This method was performed on 4 women and 6 men of 35-55 years of age. The reconstruction
surgery of the upper jaw included the closing of the oro-sinusal communication, by forming a
mucoperiosteal graft from the hard palate and repositiong and suturing it onto the defect, with later
injecting cell transplant into the surgical site. After 14 days an acrylic removable denture is
confectioned, which stimulates bone tissue growth by applying pressure. After the reconstruction
surgery of the oral cavity the communication may form again due to lack of tissue, but this method
prevents contamination of the sinus with food, as well as stimulates osteocyte growth.
Conclusions: The use of cell transplants and acrylic dentures after reconstruction surgery of the upper
jaw speeds up the healing process and forming of bone tissue.
