Abstract:
Introduction. Approximately half a century ago, allogeneic hematopoietic stem cell transplantation
(HSCT) became an essential therapeutic option for treating severe conditions, thus offering a new
chance at life for children with various hematologic and oncologic diseases.
The purpose of this study is to analyze the epidemiological peculiarities of HCAIs in children
undergoing HSCT.
Materials and Methods. A systematic review of the literature was conducted with an overview of
epidemiological aspects of HCAIs in children undergoing HSCT, related to the incidence and mortality
of the disease, isolated pathogens and the risk factors that influence the development of IAAM.
Results. HCAIs are major complications in children undergoing HSCT, with incidence rates ranging
from 5% to 50%, being higher in allogeneic compared to autologous transplants.
Bloodstream infections (BSIs) are the most frequent, with an estimated incidence of 20%-44% and a
mortality rate between 10% and 50%. HCAIs caused by resistant Gram-negative bacteria increase
mortality to 45%, while fungal infections raise it to 75%. Pneumonia and gastrointestinal infections,
including Clostridium difficile infection, are other frequently encountered complications. Urinary tract
infections are rare and are usually associated with the presence of a urinary catheter. A retrospective
study conducted over 21 years showed that 41% of children who underwent HSCT developed at least
one bloodstream infection. Another study reported an incidence of 28.2% of HCAIs in children
undergoing HSCT, with a proportion of 32.8% for BSIs. Of these, 93.4% were associated with central
venous catheterization, and the mortality rate was 36.9%. A study conducted in Italy identified
Coagulase-negative staphylococci and Enterobacteriaceae as the most frequent pathogens, each
causing approximately 25% of BSI cases, followed by Enterococci and Pseudomonas aeruginosa. The
main identified risk factors include: prolonged immunosuppression; severe and prolonged neutropenia;
use of central venous catheters; mechanical ventilation and prolonged hospitalization.
Conclusion. Children undergoing HSCT have an increased vulnerability to HCAIs due to a
combination of risk factors related to immunosuppression and invasive medical procedures. Early
identification of these factors and the implementation of rigorous strategies for infection prevention
and control are essential to reduce the incidence and impact of these complications in this vulnerable
population.
