Abstract:
Background. General anesthetics have significant effects on the hemodynamic profile of the
patient, depending on comorbidities and the associated anesthetic risk. Continuous
intraoperative monitoring of hemodynamic parameters allows for early identification of
these effects and prompt subsequent intervention.
Objective(s). To evaluate the hemodynamic profile of patients undergoing general
anesthesia based on ASA score, age and comorbidities (arterial hypertension, obesity
degree, diabetes mellitus).
Materials and methods. A prospective study was conducted on 60 patients undergoing
general anesthesia during laparoscopic cholecystectomy, in the IMU, between January and
June 2025. The analyzed hemodynamic parameters were: BP, HR, perfusion index, during preinduction, induction and the following 20 min, using the Mann-Whitney U and KruskalWallis tests.
Results. Statistically significant differences were found in the ASA I, II, III groups in
induction sBP- 123.82 vs 138.69 vs 169.21 (p<0.001), induction dBP- 74.73 vs 82.89 vs
93.64 (p=0.011), induction MAP- 90.36 vs 102.34 vs 119.36 (p=0.004), induction PI- 5.51 vs
2.69 vs 2.17 (p=0.011). In the age groups > 55 and > 65 years, differences were noted in sBP,
dBP, MAP at induction (p<0.05). In class I obesity, there were differences in sBP (p<0.044),
dBP (p<0.016), MAP (p=0.05) at 5th min, and in class III - in sBP (p=0.032), MAP (p=0.025)
at 3rd min. In hypertension, variations were noted in sBP, dBP, MAP at induction, in 1st and
2nd min (p<0.05).
Conclusion(s). The ASA score, the age and the comorbidities (obesity, hypertension) cause
variations in hemodynamic indices during induction of general anesthesia, which allows
early stratification of patients for appropriate pre-anesthetic preparation and according to
the protocol-intraoperative management.
