Profilul funcţional al macrofagelor în cadrul neoplaziilor de cervix uterin

Abstract

Histological researches in cases of cervical intraepithelial neoplasia (CIN), using the imunohistochemistry method, proves the special impact of the macrophage cell activity, as well as the other cells of the immune system (neutrophils, leukocytes). The progression of the tumor, that was considered to affect just the epithelial cells seems to involve the cells (macrophages, neutrophils, leukocytes, dendritic cells) of the immune system also, converting them for the extension of the tumor. This phenomenon is observed mostly in the macrophage cells activity, because these are the cells with one of the greatest spectrum of phagocytosis.

Cercetarile histologice in cazurile de neoplazii intraepiteliale ale colului uterin (cervixul uterin), folosind metoda imunohistochimica, demonstreaza impactul deosebit al activitatii macrofagelor, de rind cu celelalte celule ale sistemului imun. Progresia neoplaziilor ce se credea ca afecteaza numai celulele epiteliale, (se pare ca) implica si celulele imunitatii, convertindu-le in directia sustinerii extinderii tumorii. Acest fenomen se urmareste mai ales in activitatea macrofagelor, deoarece acestea sunt celulele cu unul din cele mai mari spectre de activitate fagocitara.