Abstract:
Introduction: Cerebral palsy is a non-progressive condition caused by a series of neurological
disorders that occur during fetal brain development, either before or after birth. It represents a major
global issue that leads to disability, limiting children's functionality and causing negative influences
both physically and psychologically. The aim of the study was to elucidate the effectiveness of growth
factors for cognitive and motor functionality in cerebral palsy.
Materials and Methods: 14 articles were selected and evaluated from recognized databases, such as
PubMed Central, Medline, HINARI, Google Scholar, and ResearchGate, covering the period from
2015 to 2024.
Results: Analyzing data from the literature, the patients were divided and studied into groups: in the
studied group, patients were diagnosed with perinatal cerebral palsy, generalized spastic tetraparesis,
and moderate cognitive impairments. These patients were administered intravenous platelet-rich
plasma in a dose of 25 cc (cubic centimeters), and then monitored at 24 hours, 3 months, and 6 months
after treatment, with the determination of IGF-1, PDGF, TGF, and VEGF levels before and after
treatment. Both before and after treatment, the patients were examined according to the GMFCS and
Bayley scales. Additionally, the quantity of leukocytes, granulocytes, monocytes, and platelets was
determined. It was observed that platelets were above the limit of 25,000 n/m3 post-treatment, with
their levels remaining relatively constant in the bloodstream. In some patients, platelet counts even
increased 3-5 times. Furthermore, an intensification of glucose metabolism was recorded. No adverse
effects were observed post-treatment. After treatment, improvements in cognitive and language
functions were noted according to the Bayley scale (a cognitive function assessment scale), with
children being able to communicate two or three words, and motor functions also showed
improvement.
Conclusion: Growth factor therapy in cerebral palsy produced neuroregenerative effects, improved
brain plasticity, stimulated mobility and motor skills, and recorded improvements in cognitive and
language domains.
