IRMS - Nicolae Testemitanu SUMPh: Recent submissions

  • Etiopathogenetic frontiers of trophoblastic neoplasms: a comprehensive review 
    Zingan, Mihaela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Trophoblastic neoplasms, a heterogeneous group of gestational trophoblastic diseases, present intricate challenges in deciphering their etiological and pathogenetic underpinnings. While these rare gestational ...
  • Combined administration of docetaxel and apigenin inhibits breast cancer cell survival and migration 
    Nizamudeen, Fathima (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Breast cancer, an urgent global health issue, necessitates innovative therapeutic approaches. This study focuses on HER2-positive breast cancer characterized by overexpression of the HER2 gene. Apigenin, a ...
  • Etiology and diagnostic particulars of benign ovarian tumors 
    Ambrosiv, Ana (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. According to the official data, the most widespread diseases of the reproductive system, at women of reproductive age, are ovarian tumors. The research results address the etiology and diagnosis of benign ...
  • Histological and immunohistochemical particularity of pectoralis gland cancer. Retrospective study in Oncology Institute from Moldova (2017-2022) 
    Ameena, Jasmin Rahman Nareekode Paramba Mujeeb Rahman (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Pectoral Gland cancer in men is rare and occurs in 0.5-1% of all breast cancers. The risk factors are various, but the most common are the genetic mutation of BRCA2, familial history, and hormone disbalance. ...
  • Application of virtual reality (VR) in the planning and simulation of urgent neurosurgical interventions 
    Todica, Vladislav (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Emergency neurosurgery is required for acute cerebrovascular disorders, intracranial and spinal cord traumas, and pre-cerebral artery occlusion/stenosis. It requires immediate and accurate management. Virtual ...
  • Chorio-villous mesenchymal stromal dysplasia in the course of pregnancies 
    Grosu, Eugenia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Mesenchymal stromal dysplasia is a developmental anomaly of the placenta that is characterized microscopically by dilated stem villi with a myxoid or hydropic appearance, cisterna lacunae, and lack of ...
  • The role of predictive factors of hemorrhagic transformation in patients with ischemic stroke undergoing intravenous thrombolysis 
    Frimu, Anastasia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Intravenous thrombolysis (IT) is the standard intervention for patients with ischemic stroke that demonstrates a significant rate of reduction in mortality and disability. Hemorrhagic transformation (HT) after ...
  • Treatment and rehabilitation of children with congenital, uveal and traumatic cataracts 
    Lopotencu, Francesca (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Cataract among children is one of the major causes of preventable childhood blindness, affecting approximately 200,000 children worldwide, with an estimated prevalence ranging from 3 to 6 per 10,000 new-borns. ...
  • Impact of oxidative stress on lens proteins 
    Marciuc Vlada (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The impact of oxidative stress (OS) on lens proteins is a crucial aspect of ocular health, as the lens plays an essential role in visual function. The intricate interplay between oxidative stressors and lens ...
  • Benign tumors of the vocal cords. General notions. Epidemiology, etiopathogenesis and treatment 
    Țîbulac, Daniela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Benign vocal lesions are non-malignant growths of abnormal tissue on the vocal cords. The common benign lesions of vocal cord are singer’s nodule, polyps, papilloma, polypoid degeneration (Reinke’s edema) and ...
  • Heterochromia: causes, risk factors, treatment 
    Aramă, Crina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. According to the National Center for Biotechnology Information, approximately 1% of the global population is diagnosed with heterochromia. Iris heterochromia is the uneven pigmentation of the iris, either ...
  • Evolutionary methods to identify the ocular lymphatic 1,61 1,61 system 
    Ciorba, Nadejda (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Compared to blood vessels, lymphatics can be identified much harder in the human body, especially at the eye level. Lymphatics very often present an irregular, collapsed structure, which creates difficulty ...
  • Modern approaches to glaucoma surgical treatment 
    Omer, Levy (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Primary open-angle glaucoma, the leading cause of irreversible blindness globally, affects over 3% of people over 40 and is expected to exceed 111 million cases by 2040. Traditional management methods include ...
  • Dry eye syndrome among young people: implications, risk factors and perspectives 
    Vlas, Daria (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Dry eye syndrome (DES) has become a major problem among young people, being associated with prolonged exposure to digital screens and psychological stress. Increased prevalence and impact on eye health have ...
  • Genetically determined pigmentary retinopathy (PR) in systemic diseases 
    Moldavskaia, Zlata (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The term "pigmentary retinopathy" broadly refers to a widespread alteration of the retina and pigment epithelium preventing normal vision. The condition is clinically diverse and can be inherited in various ...
  • Transthyretin cardiac amyloidosis and bone scintigraphy: state of the art detection in rare diseases 
    Asavei, Letiția; Cârciumaru, Marius; Ciocoiu-Bunilă, Ioan Vlad; Gorea, Diana Valentina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Transthyretin cardiac amyloidosis (ATTR-ca) is a rare protein deposition disease characterized by the accumulation of amyloid in the myocardium altering its function. Diagnosing it has proven to be a challenge ...
  • The impact of the 3 endothelium derived gasses (H2S, No, Co) on vascular endothelium homeostasis 
    Leca, Magdalena (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Vascular endothelial fulfills a lot of functions having a decisive role in the control of circulatory and general homeostasis. Among the endothelium derived factors three gasses occupy a special position being ...
  • The pathophysiology of iron deficiency in the body, endangerment of the absorption, transport and storage of the cation. The main mechanisms 
    Gumeniuc, Alexandra (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Iron plays an important role in a multitude of physiological processes, such as the transport of oxygen from the lungs to the tissues, the release of molecular oxygen from organic compounds, favors the exchange ...
  • The role of genetic aspects in pathophysiology of cushing syndrome 
    Pascari, Anastasia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Cushing's syndrome is considered a rare disease with an incidence of 0.2– 0.5 million population per year, with an average age of 41 years at diagnosis and 1–2 cases per 100,000 population per year. As known, ...
  • The morphopathological aspect of metabolicassociated fatty liver disease 
    Trocin, Cristina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Being proposed in 2020, the novel terminology for Metabolic-Associated Fatty Liver Disease (MAFLD) involves the strong association of fatty liver disease with metabolic factors rather than NAFLD, the term ...