Browsing MedEspera 2024 by Issue Date

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  • Exploring the role of N-terminal pro-brain natriuretic peptide as a diagnostic biomarker in Kawasaki disease 
    Duca, Alexandra (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Kawasaki disease (KD), also known as mucocutaneous lymph node syndrome, is an acute febrile illness of unknown cause that stands out as a unique and challenging pediatric vasculitis, characterized by acute ...
  • Metabolic peculiarities of immunotherapeutic medicines (chimeric antigen receptor t cells) used in cancer treatment (b-cell acute lymphoblastic leukemia) 
    Sluchin, Andrei (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. In the dynamic realm of cancer therapeutics, many studies explore the metabolic nuances of Chimeric Antigen Receptor (CAR) T-cell therapy in treating B-cell acute lymphoblastic leukemia (B-ALL). Understanding ...
  • The interplay of growth hormone, insulin-like growth factors, and cancer susceptibility: a medical perspective 
    Briceag, Maria (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. GH and IGF-I, known for promoting growth, are under scrutiny for their potential involvement in cancer progression. While we understand their normal effects, the disruption caused by these factors and their ...
  • Biochemical aspects of heart diseases in patients with diabetes mellitus 
    Parapuravalappil Sathyan, Krishnadas (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The prevalence of diabetes mellitus is continuously increasing globally and is estimated to reach approx. 366 million by 2030. According to the latest research, the cardiovascular changes due to diabetes are ...
  • Biochemical changes of the vascular endothelium in diabetic pathology 
    Stici, Vlada (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Diabetes mellitus (DM) is a multifactorial pathology that has become a worldwide problem due to its rapid spread and progression. Persistent hyperglycemia in DM induces disruption of vascular homeostasis by ...
  • The role of leptin in the pathogenesis of metabolic dysfunction-associated fatty liver disease 
    Darii, Felicia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Metabolic dysfunction-associated fatty liver disease (MAFLD) has become one of the leading causes of end-stage liver disease. Its pathogenesis is not fully understood, but leptin may contribute to the development ...
  • Psycho-emotional state before and after the injectable procedure 
    Cazacu, Victoria (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Persons who would like a change of the exterior, including those who are often afraid to start the aesthetic intervention for reasons when they want to stop the procedure, will look worse or are afraid of the ...
  • Disruption of the immune response in patients with obesity during COVID-19 
    Zahlîstnîi, Bogdan (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Obesity was one of the frequent comorbidities in hospitalized patients with SARSCoV-2 infection. The recent studies of Covid-19 outcomes have noticed a correlation between obesity and more severe clinical ...
  • GLUTs genetic defects as causes of diabetes 
    Ciuchitu, Alina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Diabetes mellitus (DM) is a chronic disease marked by insulin secretion or action defects. The cause of diabetes can be genetic defects of glucose transporters – GLUT, the most characteristic being the GLUT2 ...
  • Role of mineralocorticoid receptor pathway in the pathogenesis of diabetic retinopathy 
    Toncoglaz, Alexandra (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Diabetic retinopathy (DR) represents a major cause of irreversible blindness among the working-age population. Aldosterone has an important role in the pathogenesis of DR, through vascular regulation, oxidative ...
  • Hereditary angioedema with C1 inhibitor deficiency 
    Butucel, Ana (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Hereditary angioedema (HAE) is a rare autosomal dominant disease with deficiency or/and dysfunction of C1 inhibitor, caused by mutations in the C1-INH gene. HAE is characterized by potentially life-threatening ...
  • Cancer never takes a break — a new reality, the same relentless adversary 
    Luca, Ion (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Lung cancer presents a significant global health challenge, posing a pervasive threat to individuals worldwide. It stands as a major concern, often linked to severe prognoses and a substantial impact on quality ...
  • Portal hypertension: diagnosis and treatment management 
    Toha, Valeria (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Portal hypertension is responsible for the more severe and even lethal complications of chronic liver disease and cirrhosis. Aim of study. Evaluation of the effect of ozone therapy on the state of circulation ...
  • Impact of new classification of copd on assessment of severity 
    Gîlca, Gabriela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Chronic obstructive pulmonary disease is a respiratory disease caused by abnormalities of the airways, alveoli, accompanied by chronic respiratory symptoms (dyspnea, cough, expectoration), characterized by a ...
  • Genetic variants of COMT gene expression and influence on pain perception 
    Crasevici, Irina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Catechol-O-methyltransferase (COMT) is a pivotal enzyme responsible for deactivating biologically active catechols, including crucial neurotransmitters such as dopamine, norepinephrine, and adrenaline. These ...
  • Dietary habits of patients with ischemic heart disease 
    Abraș, Tatiana (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Ischemic heart disease continues to be the leading cause of mortality, morbidit y and high hospitalization rates in both high-income and developing countries. According to data from the World Health Organization, ...
  • Personalized medicine and cardiovascular diseases 
    Sooltan, Abdool Rahim (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. There was a remarkable growth in scientific publication on personalized medicine within the past few years in the field of cardiovascular disease. In the era of personalized/precision medicine the combination ...
  • External validation of a new prognostic score for mortality in the first 3 months of patients on the waiting list for liver transplantation 
    Pîrvu, Victor (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Viral liver cirrhosis is one of the most serious problems for the population due to its global spread, increased morbidity and mortality, and the high degree of disability caused by its rapid progression. Aim ...
  • What do students know about sexually transmitted diseases and methods of contraception? A survey study about knowledge and sexual risk behaviours among university students 
    Jurca, Denisa-Amalia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Sexual life is of considerable importance, particularly in youngsters, not only because of its Sexual life is extremely important, especially for young people, not just because it affects intellectual development ...
  • Vaginal cones with vibrating ball inside in pelvic floor dysfunction 
    Villani, Federico; Rigano, Damiano; Moratti, Elisabetta; Minopoli, Bruno; Guglielmino, Alessandra; Todut, Oana; Ciobanu, Victoria; Furau, Roxana; Furau, Cristian (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. These are the first results of an ongoing multicentrum observative trial to determine the effectiveness of vaginal cones (VC) in pelvic floor (PF) training. Because of a high economic burden of urine incontinence ...

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