Abstract:
Introduction. The use of nanotechnology in medicine, and more specifically in drug delivery, is
rapidly spreading. Numerous substances are currently being researched for drug delivery and, in
particular, cancer therapy.
Aim of study. This study aims to describe biopharmaceutical peculiarities of liposomes and
nanoparticles in the human body.
Methods and materials. A bibliographic study of scientific literature specialized at
biopharmaceutical peculiarities of liposomes and nanoparticles in the human body.
Results. Nanoscale drug design has been widely studied and is by far the most advanced
technology in nanoparticle applications due to its potential advantages, such as the ability to
modify properties like solubility, drug release profiles, diffusivity, bioavailability and
immunogenicity. Nanomedicines have improved solubility due to the presence of both hydrophilic
and hydrophobic environments. A number of well-known nanodrugs are already available on the
market. Since 1995, 50 nanopharmaceuticals have received Food and Drug Administration (FDA)
approval and are currently available for clinical use. Pharmaceutical sciences use nanoparticles to
reduce the toxicity and side effects of drugs and, until recently, have not realized that the delivery
systems themselves may impose risks to the patient.
Conclusion. The benefits of nanoparticles for modern medicine are numerous. Indeed, there are
some cases where nanoparticles enable analyses and therapies that simply cannot be performed
otherwise. However, nanoparticles also bring with them unique challenges for the environment
and society, particularly in terms of toxicity.
