Potential applications of nanotechnologies and bioengineering in dupuytren's disease treatment

Abstract

Introduction. Dupuytren's disease, characterized by the formation of knots and cords in the palm and finger fascia of the hand, needs significant challenges in treatment due to its progressive nature and tendency for recurrence. In recent years, nanotechnology and bioengineering have emerged as a promising avenue for addressing the complexities of this condition. Aim of study. The review explores the emerging applications of nanotechnologies and bioengineering in the treatment of Dupuytren's disease, by examining recent advancements. Methods and materials. A comprehensive search of electronic databases including Google Scholar, PubMed, Scopus, and Web of Science was conducted to identify relevant studies in the period of time 2020-2024. The search strategy employed a combination of keywords related to nanotechnology, bioengineering, Dupuytren disease, and treatment modalities. Results. Key areas of focus include targeted drug delivery using engineered nanoparticles, that can be designed to deliver therapeutic agents directly to affected tissues, increasing treatment effectiveness while minimizing side effects. The development of nanostructured scaffolds, that are designed to support tissue regeneration and inhibit contracture progression in affected areas of the hand, present a promising approach for tissue engineering. These scaffolds can mimic the extracellular matrix and provide a supportive environment for cells to grow and regenerate, potentially offering a novel approach to treating Dupuytren disease. Nanoparticle-based imaging involves the use of nanoparticles as contrast agents for advanced imaging techniques such as magnetic resonance imaging, computed tomography, or ultrasound. These nanoparticles are designed to specifically target and accumulate in areas affected by Dupuytren disease, providing enhanced visualization of disease-related structures and processes. By harnessing the unique properties of nanomaterials, researchers aim to enhance the efficacy of current treatments, minimize side effects, and ultimately improve outcomes for patients with Dupuytren's disease. Conclusion. Despite the early stage of research in this field, the potential of nanotechnology and bioengineering to revolutionize Dupuytren's disease treatment highlights promising advancements. However, further studies are needed to optimize these approaches, evaluate their long-term safety and efficacy, and develop clinically feasible methods for their application in Dupuytren disease. and finger fascia of the hand, needs significant challenges in treatment due to its progressive nature and tendency for recurrence. In recent years, nanotechnolo gy and bioengineering have emerged as a promising avenue for addressing the complexities of this co ndition. Aim of study. The review explores the emerging applications of nanotec hnologies and bioengineering in the treatment of Dupuytren's disease, by e xamining recent advancements. Methods and materials. A comprehensive search of electronic databases including Google Scholar, PubMed, Scopus, and Web of Science was conducted to identify relevant studies in the period of time 2020-2024. The search strategy employed a combina tion of keywords related to nanotechnology, bioengineering, Dupuytren disease, and trea tment modalities. Results. Key areas of focus include targeted drug delivery using engine ered nanoparticles, that can be designed to deliver therapeutic agents directly to aff ected tissues, increasing treatment effectiveness while minimizing side effects. The developme nt of nanostructured scaffolds, that are designed to support tissue regeneration and inhibit contracture progression in affected areas of the hand, present a promising approach for tissue engineering. These sc affolds can mimic the extracellular matrix and provide a supportive environment for cells to grow and regenerate, potentially offering a novel approach to treating Dupuytren d isease. Nanoparticle-based imaging involves the use of nanoparticles as contrast agents for advanced imaging techniques such as magnetic resonance imaging, computed tomography, or ultrasound. These nanoparticles are designed to specifically target and accumulate in areas affe cted by Dupuytren disease, providing enhanced visualization of disease-related structures and proc esses. By harnessing the unique properties of nanomaterials, researchers aim to enhance the efficacy of current treatments, minimize side effects, and ultimately improve outcomes fo r patients with Dupuytren's disease. Conclusion. Despite the early stage of research in this field, th e potential of nanotechnology and bioengineering to revolutionize Dupuytren's disease treatment hi ghlights promising advancements. However, further studies are needed to optimize these approach es, evaluate their long-term safety and efficacy, and develop clinically feasible methods for their application in Dupuytren disease.