The Materials of the National Scientific Conference with International Participation „Cells and tissues transplantation. Actualities and perspectives. The 3rd edition” dedicated to the 80th anniversary of the founding of Nicolae Testemitanu State University of Medicine and Pharmacy. Chisinau, March 21-22, 2025: [Abstracts]: Recent submissions

  • Neural stem cell transplantation for neurodegenerative diseases 
    Jecova, Svetlana; Protopop, Svetlana (CEP Medicina, 2025)
    Background. Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, are severely disabling and ultimately fatal conditions that affect ...
  • Biomaterials and nanotechnology in dental osseointegration 
    Babuci, Angela; Paz, Eli; Zorina, Zinovia; Stratulat, Silvia; Lehtman, Sofia; Calancea, Sergiu (CEP Medicina, 2025)
    Introduction: The osseointegration is a process of bone ingrowth into the surface of a load-carrying implant. Due to its low elastic modulus, excellent biocompatibility and resistance to corrosion, titanium is the most ...
  • Tissue and cells transplantation in the Republic of Moldova, trendlines 
    Nacu, Viorel; Stepa, Serghei; Coșpormac, Igor; Cociug, Adrian; Cobzac, Vitalie; Guțu-Bahov, Cornelia; Tambalari, Tatiana (CEP Medicina, 2025)
    The development of tissue transplantation in the Republic of Moldova began in the 1960s with the use of bone grafts. This laid the foundation for the establishment of national infrastructure for tissue preservation and ...
  • Stem cell transplantation in infertility treatment: new perspectives in regenerative medicine 
    Ivanova, Svetlana; Foca, Ecaterina (CEP Medicina, 2025)
    Background. Female infertility is a multifactorial condition caused by factors such as ovarian dysfunction, endometrial disorders, hormonal imbalances, and age-related decline in reproductive potential. Stem cell ...
  • Agent-based modeling of fluid dynamics in lung tissue engineering 
    Iapăscurtă, Victor (CEP Medicina, 2025)
    Introduction: In tissue engineering for lung applications, understanding and controlling fluid dynamics within engineered constructs is paramount. Agent-based modeling (ABM) offers a powerful framework to simulate complex ...
  • Building a RAG system for tissue engineering: insights from domain specific text and sepsis management 
    Iapăscurtă, Victor (CEP Medicina, 2025)
    Introduction: Tissue engineering (TI) is a complex field that requires access to specific domain knowledge. Large Language Models (LLMs) are powerful but limited by their training data. Retrieval Augmented Generation ...
  • Exploring trabecular meshwork stem cells: potential roles, therapeutic implications and challenges in glaucoma 
    Iacubițchii, Maria; Bendelic, Eugeniu; Țarălungă, Tatiana; Nacu, Viorel (CEP Medicina, 2025)
    Introduction: Recent investigations surrounding trabecular mesh (TM) stem cells have generated significant interest due to their possible role in glaucoma treatment. Trabecular mesh cells are crucial in maintaining IOP ...
  • Novel therapies in osteoarthritis current status and perspectives 
    Labusca, Luminița (CEP Medicina, 2025)
    Osteoarthritis (OA) remains a major contributor to disability worldwide, placing a significant burden on healthcare systems. Current treatment strategies predominantly focus on symptom management rather than halting or ...
  • Cellular therapy with growth factors: a promising neuroregenerative approach in cerebral palsy 
    Iachimovschi, Dumitrița; Stratu, Ecaterina; Catcov, Carolina (CEP Medicina, 2025)
    Introduction: Cerebral palsy is a non-progressive condition caused by a series of neurological disorders that occur during fetal brain development, either before or after birth. It represents a major global issue that ...
  • Liver transplantation for hepatocellular carcinoma 
    Hotineanu, Adriana; Burgoci, Sergiu (CEP Medicina, 2025)
    Introduction. Hepatocellular carcinoma is one of the most frequent complications of advanced liver cirrhosis, associated with high mortality. Liver transplantation is an effective therapeutic solution in selected cases, ...
  • Challenges in the use of glucocorticoids in transplantology 
    Guțu, Ina; Bacinschi, Nicolae; Țurcan, Lucia; Caracas, Anastasia; Mihalachi-Anghel, Maria (CEP Medicina, 2025)
    Introduction. Glucocorticoids (GCs) have long time played a key role in solid organ transplantation (SOT), thanks to their strong anti-inflammatory and immunosuppressive effects. However, their use presents a significant ...
  • The role of glycation on transplantology methods in cancer treatment 
    Grusac, Evgheni; Tagadiuc, Olga; Munteanu, Roman; Pantea, Valeriana; Sardari, Veronica (CEP Medicina, 2025)
    Background. Advanced glication end products (AGEs) are formed in result of Millard reaction in hiperglycemic conditions caused by Warburg`s effect. Many studies have shown the presence of AGEs in neoplastic tissues through ...
  • Regenerative approaches for managing percutaneous nephrostomy complications: stem cell and tissue engineering strategies 
    Goras, Valeria; Tanase, Adrian (CEP Medicina, 2025)
    Introduction: Percutaneous nephrostomy (PCN) is a crucial intervention for urinary tract decompression in obstructive uropathy, malignancy, and infection. However, it carries significant risks, including hemorrhage, ...
  • Material design in hard tissue engineering 
    Jian, Mariana; Codrea, Cosmin; Spoiala, Angela; Ficai, Denisa; Nacu, Viorel; Ficai, Anton (CEP Medicina, 2025)
    Introduction: Considering the high incidence and the relatively large amount needed, the overall market share of the bone grafting materials is ~49% of the total field of biomaterials and thus many researchers focused ...
  • Challenges in the treatment of ocular surface pathologies 
    Cușnir, Valeriu; Dumbraveanu, Lilia; Lupan, Valentina; Cociug, Andrian; Procopciuc, Vitalie; Cușnir, Valeriu V.; Balba, Rodica; Bostan, Mihaela; Nacu, Viorel (CEP Medicina, 2025)
    Introduction. Tissue transplantation at the ocular surface for therapeutic, tectonic, reconstructive, or optical purposes is a routine practice among ophthalmic surgeons worldwide. The main ocular surface pathologies ...
  • Nanocarriers that may bypass the blood-brain barrier 
    Croitoru, Dan; Todica, Vladislav; Andronachi, Victor; Andrusca, Alexandru; Visnevschi, Sergiu (CEP Medicina, 2025)
    Introduction: The blood-brain barrier (BBB), blood-cerebrospinal fluid barrier (BCSFB) and bloodbrain tumour barrier (BBTB) are regarded as potential barriers for drug delivery. Nanocarriers are designed in order to bypass ...
  • The prospects of selective JAK inhibitors in hematopoietic stem cells transplantation 
    Cozma, Octavian; Tonofa, Maria; Timercan, Tatiana (CEP Medicina, 2025)
    Introduction. Hematopoietic stem cell transplantation (HSCT) represents a life-saving therapy for hematological malignancies, but its efficacy is often compromised by graft-versus-host disease (GVHD). GVHD remains a major ...
  • Clinical case: the impact of renal transplantation in the patient with renal pathology and gout 
    Cornea, Cornelia; Ceban, Emil; Rotaru, Larisa; Groppa, Liliana; Sasu, Boris; Tagadiuc, Olga; Romanciuc, Grigore; Timbalari, Tatiana; Buga, Diana; Nacu, Viorel (CEP Medicina, 2025)
    Introduction:Renal transplantation is a radical treatment option for patients with chronic kidney disease (CKD), significantly impacting those with coexisting renal pathology, such as gout. The use of immunosuppressants ...
  • Cancer stem cells and tumor microenvironment: implications for therapy resistance and novel strategies 
    Colibaba, Vasile; Sardari, Veronica (CEP Medicina, 2025)
    Background. Cancer stem cells (CSCs) represent a distinct subpopulation of tumors, characterized by self-renewal capacity and multilineage differentiation potential. These cells interact dynamically with the tumor ...
  • The role of miR-152-5p in renal transplantation 
    Cojocaru, Madalina; Ambros, Ala (CEP Medicina, 2025)
    Introduction. miR-152-5p is a microRNA involved in the regulation of gene expression at the posttranscriptional level, primarily expressed in hematopoietic cells. It impacts the regulation of genes involved in T cells and ...

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