IRMS - Nicolae Testemitanu SUMPh: Recent submissions

  • Anatomical clinical aspect in the etiology of inguinal hernia 
    Guzun, Gheorghe; Turchin, Radu (CEP Medicina, 2026)
    Background. Decreased tone of the anterolateral abdominal wall muscles, actually is considered the main etiological factor in the appearance of inguinal hernia. Taking into consideration that the spinal nerves have the ...
  • Strategies for mitigating oxidative stress in transplanted cells 
    Satheswaran, Maharajan; Cebotari, Dionisie; Railean, Nadejda; Tagadiuc, Olga; Sardari, Veronica (CEP Medicina, 2026)
    Introduction. Transplantation is a vital treatment for organ failure, degenerative diseases and severe tissue injuries. Challenge being, the poor function, survival of transplanted cells caused by oxidative stress. During ...
  • The role of angiogenesis in ischemic disease 
    Grusac, Evgheni; Cebotari, Dionisie; Railean, Nadejda; Oboroc, Sandu; Sardari, Veronica (CEP Medicina, 2026)
    Background. Ischemic heart disease, myocardial infarction, ischemic stroke, and peripheral arterial disease are non-communicable, highly disabling conditions with high incidence and mortality rates. It is well recognized ...
  • The role of copper in angiogenesis 
    Grusac, Evgheni; Pantea, Valeriana; Railean, Nadejda; Stratulat, Silvia; Sardari, Veronica (CEP Medicina, 2026)
    Background. In disease conditions, the goal of therapeutic targeting of the angiogenic process is to normalize vasculature in target tissues by enhancing angiogenesis, where reduced vascularity and blood flow occur, such ...
  • Evaluare genetică și biochimică la pacienții cu suspecție de boală mitocondrială 
    Secu, Doina; Blăniță, Daniela; Ușurelu, Natalia; Sacară, Victoria (Instituţia Medico-Sanitară Publică Institutul Mamei și Copilului, 2025)
    Introduction: Mitochondrial diseases (MD) are a group of rare, genetically inherited disorders caused by defects in mitochondrial function, particularly in oxidative phosphorylation, leading to impaired cellular energy ...
  • Diagnosticare moleculară: cheia viitorului medical în Republica Moldova 
    Sacară, Victoria; Coliban, Iulia; Secu, Doina; Dorif, Alexandr; Boiciuc, Constantin; Egorov, Vladimir (Instituţia Medico-Sanitară Publică Institutul Mamei și Copilului, 2025)
    Introduction: Molecular diagnosis represents an essential frontier in modern medicine, offering promising perspectives for managing genetic and hereditary diseases. Its relevance is growing in the context of expanding ...
  • The role of odontogenic infection in the onset and evolution of focal disease 
    Ciobanu, Sergiu; Marcu, Diana; Roman, Ion; Musteață, Olesea (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2026)
  • Lung transplantation in the management of cystic fibrosis 
    Rotaru, Ludmila; Rotaru, Tudor (CEP Medicina, 2026)
    Introduction. Cystic fibrosis (CF) is an autosomal recessive genetic disorder caused by mutations in the CFTR gene, affecting multiple organs, particularly the lungs, and leading to progressive respiratory failure. Despite ...
  • Fecal microbiota transplantation in metabolic syndrome 
    Potînga, Irina; Protopop, Svetlana (CEP Medicina, 2026)
    Introduction. Metabolic syndrome (MetS) is a multifactorial disease, and the gut microbiota plays an important role in its pathogenesis. Moreover, recent studies suggest associations between gut dysbiosis and components ...
  • Pancreatic islet cell autotransplantation as a therapeutic option in chronic pancreatitis complicated by pancreatic pseudocyst 
    Pîrțac, Mihail; Berliba, Sergiu; Chira, Inga; Ciobanu, Lorina (CEP Medicina, 2026)
    Introduction. In the management of chronic pancreatitis (CP), pancreatic pseudocyst (PCP) is a complication that requires the attention of surgeons, provided that it is non-neoplastic, recurrent, >6 cm in size, persists ...
  • Implementing regenerative medecine across surgical pathways in liver cirrhosis 
    Negarî, Nadejda; Minchevici, Delia; Cazacov, Vladimir; Nacu, Viorel (CEP Medicina, 2026)
    Introduction: Liver cirrhotic patients often face surgical and interventional procedures, such as hepatectomy with modulation of future liver remnant, portoenterostomy in cases of biliary atresia, transjugular intrahepatic ...
  • Translational perinatal medicine in non-immune fetal hydrops: from prenatal to modern cellular therapies 
    Neagu, Anastasia (CEP Medicina, 2026)
    Introduction. Non-immune fetal hydrops (NIHF) represents one of the most severe conditions in fetal medicine, characterized by the pathological accumulation of fluid in at least two fetal compartments and associated with ...
  • Perinatal stem cells in regenerative medecine and transplantation: current applications and future perspectives 
    Mudzhuk, Alona; Nacu, Viorel (CEP Medicina, 2026)
    Introduction. The preservation of perinatal biological materials - umbilical cord blood, umbilical cord tissue, and placental tissue - has become one of the most important developments in modern preventive and regenerative ...
  • Restoring thyroid function with tissue-engineered products after total thyroidectomy 
    Minchevici, Delia; Negarî, Nadejda; Bour, Alin; Gîlea, Angela; Nacu, Viorel (CEP Medicina, 2026)
    Introduction: Post-thyroidectomy hypothyroidism is a common complication of total thyroid removal, traditionally managed with lifelong hormone replacement therapy. Thyroid models developed through tissue engineering ...
  • Diabetogenic efect of immunosuppressive drugs in transplant recipients 
    Mihalachi-Anghel, Maria; Bacinschi-Gheorghița, Stela; Bacinschi, Nicolae (CEP Medicina, 2026)
    Introduction. In organ transplant patients, new onset diabetes mellitus after transplantation (NODAT) has been found to be a frequent and serious complication. The use of immunosuppressive drugs after transplantation has ...
  • Thirteen years of activity of the human tissue bank at the clinical hospital of orthopedics and traumatology 
    Nacu, Viorel; Stepa, Serghei; Cospormac, Igor; Cociug, Adrian; Cobzac, Vitalie; Țîmbalari, Tatiana (CEP Medicina, 2026)
    Introduction. Tissue transplantation represents an essential component of modern regenerative and reconstructive medicine. In the Republic of Moldova, this field has evolved progressively since the 1960s, beginning with ...
  • Sindroamele de lipodistrofie 
    Colța, Olga; Harea, Dumitru; Șeremet, Aristia (Instituţia Medico-Sanitară Publică Institutul Mamei și Copilului, 2025)
    Sindroamele de lipodistrofie (SL) se caracterizează prin lipsa generalizată sau parțială a țesutului adipos, în absența deprivării nutriționale sau catabolismului accelerat. Se identifică 4 forme: lipodistrofia generalizată ...
  • Sindromul MEN2A, cu debut în copilărie 
    Gangan, Diana (Instituţia Medico-Sanitară Publică Institutul Mamei și Copilului, 2025)
    Introducere: Neoplazii endocrine multiple subtipul 2A este sindromul genetic care se manifestă prin feocromocitom, carcinom medular a glandei tiroide și hiperparatiroidism. Scopul lucrării: Analiza particularităților ...
  • Disfuncțiile endocrine în sindromul Down 
    Clipii, Olga (Instituţia Medico-Sanitară Publică Institutul Mamei și Copilului, 2025)
    Introducere: Sindromul Down (SD) este asociat cu o serie de disfuncții endocrine care influențează semnificativ starea și dezvoltarea copiilor. Cele mai frecvente tulburări endocrine sunt dereglările tiroidiene, boala ...
  • Simptomele sindromului Papillon-Lefèvre (PLS) la un copil de șase ani: raport de caz 
    Bauchina, Alisa; Porosencov, Egor; Dolapciu, Elena; Tutueva, Tatyana; Sacara, Victoria (Instituţia Medico-Sanitară Publică Institutul Mamei și Copilului, 2025)
    Papillon-Lefèvre Syndrome (PLS), a rare autosomal recessive disorder (1/1,000,000) caused by cathepsin C gene mutation with severe periodontitis following early tooth loss. Methods involved a thorough clinical evaluation ...